ENZYME

ENZYME entry: EC 3.4.22.58

Accepted Name

Caspase-5.

Alternative Name(s)

CASP-5.

ICErel-III.

Ich-3.

ICH-3 protease.

Reaction catalysed

Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-

Comment(s)

This enzyme is part of the family of inflammatory-caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-4 (EC 3.4.22.57) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice.
Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
The enzyme is able to cleave itself and the p30 caspase-1 precursor, but is very inefficient at generating mature interleukin-1-beta (IL-1-beta) from pro-IL-1-beta.
Both this enzyme and caspase-4 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17).
Unlike caspase-4, this enzyme can be induced by lipopolysaccharide.
Belongs to peptidase family C14.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature