ID   3.4.22.58
DE   caspase-5.
AN   CASP-5.
AN   ICErel-III.
AN   Ich-3.
AN   ICH-3 protease.
CA   Strict requirement for Asp at the P1 position. It has a preferred
CA   cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-
CA   Asp-|-.
CC   -!- This enzyme is part of the family of inflammatory-caspases, which
CC       also includes caspase-1 (EC 3.4.22.36) and caspase-4 (EC 3.4.22.57)
CC       in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and
CC       caspase-14 in mice.
CC   -!- Contains a caspase-recruitment domain (CARD) in its N-terminal
CC       prodomain, which plays a role in procaspase activation.
CC   -!- The enzyme is able to cleave itself and the p30 caspase-1 precursor,
CC       but is very inefficient at generating mature interleukin-1beta
CC       (IL-1beta) from pro-IL-1beta.
CC   -!- Both this enzyme and caspase-4 can cleave pro-caspase-3 to release
CC       the small subunit (p12) but not the large subunit (p17).
CC   -!- Unlike caspase-4, this enzyme can be induced by lipopolysaccharide.
CC   -!- Belongs to peptidase family C14.
DR   P51878, CASP5_HUMAN;  Q504J1, CASPB_DANRE;
//