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ENZYME entry: EC 126.96.36.199
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|Apoptotic protease Mch-2.|
|Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-|
- Caspase-6 is an effector/executioner caspase, as are caspase-3
(EC 188.8.131.52) and caspase-7 (EC 184.108.40.206).
- These caspases are responsible for the proteolysis of the majority of
cellular polypeptides, (e.g. poly(ADP-ribose) polymerase (PARP)),
which lead to the apoptotic phenotype.
- Caspase-6 can cleave its prodomain to produce mature caspase-6, which
directly activates caspase-8 (EC 220.127.116.11) and leads to cytochrome c
release from the mitochondria; the release of cytochrome c, which is
an essential component of the intrinsic apoptosis pathway.
- Can also cleave and inactivate lamins, the intermediate filament
scaffold proteins of the nuclear envelope, leading to nuclear
fragementation in the final phases of apoptosis.
- Belongs to peptidase family C14.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
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