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ENZYME entry: EC

Accepted Name
Alternative Name(s)
Apoptotic protease Mch-2.
Reaction catalysed
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-
  • Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC and caspase-7 (EC
  • These caspases are responsible for the proteolysis of the majority of cellular polypeptides, (e.g. poly(ADP-ribose) polymerase (PARP)), which lead to the apoptotic phenotype.
  • Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC and leads to cytochrome c release from the mitochondria; the release of cytochrome c, which is an essential component of the intrinsic apoptosis pathway.
  • Can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragementation in the final phases of apoptosis.
  • Belongs to peptidase family C14.
PRIAM enzyme-specific profiles3.4.22.59
KEGG Ligand Database for Enzyme Nomenclature3.4.22.59
IUBMB Enzyme Nomenclature3.4.22.59
MEDLINEFind literature relating to
Q3T0P5, CASP6_BOVIN;  P55212, CASP6_HUMAN;  O08738, CASP6_MOUSE;  
O35397, CASP6_RAT;  

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