To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 3.4.22.59

Accepted Name
Caspase-6.
Alternative Name(s)
Apoptotic protease Mch-2.
CASP-6.
Mch2.
Reaction catalysed
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-
Comment(s)
  • Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-7 (EC 3.4.22.60).
  • These caspases are responsible for the proteolysis of the majority of cellular polypeptides, (e.g. poly(ADP-ribose) polymerase (PARP)), which lead to the apoptotic phenotype.
  • Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC 3.4.22.61) and leads to cytochrome c release from the mitochondria; the release of cytochrome c, which is an essential component of the intrinsic apoptosis pathway.
  • Can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragementation in the final phases of apoptosis.
  • Belongs to peptidase family C14.
Cross-references
PROSITEPDOC00864
BRENDA3.4.22.59
EC2PDB3.4.22.59
ExplorEnz3.4.22.59
PRIAM enzyme-specific profiles3.4.22.59
KEGG Ligand Database for Enzyme Nomenclature3.4.22.59
IUBMB Enzyme Nomenclature3.4.22.59
IntEnz3.4.22.59
MEDLINEFind literature relating to 3.4.22.59
MetaCyc3.4.22.59
UniProtKB/Swiss-Prot
Q3T0P5, CASP6_BOVIN;  P55212, CASP6_HUMAN;  O08738, CASP6_MOUSE;  
O35397, CASP6_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-