ENZYME

ENZYME entry: EC 3.4.22.64

Accepted Name

Caspase-11.

Alternative Name(s)

CASP-11.

Reaction catalysed

Strict requirement for Asp at the P1 position and has a preferred cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-|-

Comment(s)

Part of the family of inflammatory-caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice.
Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation.
Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide.
Not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1-beta (IL-1-beta) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions.
Belongs to peptidase family C14.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature