ID   3.4.22.68
DE   Ulp1 peptidase.
AN   Smt3-protein conjugate proteinase.
AN   Ubl-specific protease 1.
AN   Ulp1.
AN   Ulp1 endopeptidase.
AN   Ulp1 protease.
CA   Hydrolysis of the alpha-linked peptide bond in the sequence Gly-
CA   Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like
CA   modifier (SUMO) propeptide, Smt3, leading to the mature form of the
CA   protein. A second reaction involves the cleavage of an epsilon-linked
CA   peptide bond between the C-terminal glycine of the mature SUMO and the
CA   lysine epsilon-amino group of the target protein.
CC   -!- The enzyme from Saccharomyces cerevisiae can also recognize small
CC       ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both
CC       SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation
CC       (epsilon-linked peptide bonds) reactions.
CC   -!- Ulp1 has several functions, including an essential role in
CC       chromosomal segregation and progression of the cell cycle through the
CC       G2/M phase of the cell cycle.
CC   -!- Belongs to peptidase family C48.
PR   PROSITE; PDOC50600;
DR   Q94F30, ESD4_ARATH ;  Q9LSS7, RUBP1_ARATH;  Q9P0U3, SENP1_HUMAN;
DR   P59110, SENP1_MOUSE;  Q5RBB1, SENP1_PONAB;  Q9HC62, SENP2_HUMAN;
DR   Q91ZX6, SENP2_MOUSE;  Q5R7K7, SENP2_PONAB;  Q9EQE1, SENP2_RAT  ;
DR   Q9H4L4, SENP3_HUMAN;  Q9EP97, SENP3_MOUSE;  Q96HI0, SENP5_HUMAN;
DR   Q8WP32, SENP5_MACFA;  Q6NXL6, SENP5_MOUSE;  Q9GZR1, SENP6_HUMAN;
DR   Q6P7W0, SENP6_MOUSE;  A7MBJ2, SENP7_BOVIN;  Q9BQF6, SENP7_HUMAN;
DR   Q8BUH8, SENP7_MOUSE;  Q54XR2, SENP8_DICDI;  Q96LD8, SENP8_HUMAN;
DR   Q9D2Z4, SENP8_MOUSE;  Q5FVJ8, SENP8_RAT  ;  Q09353, SENP_CAEEL ;
DR   Q8GYL3, ULP1A_ARATH;  O65278, ULP1B_ARATH;  Q8RWN0, ULP1C_ARATH;
DR   Q2PS26, ULP1D_ARATH;  O42957, ULP1_SCHPO ;  Q02724, ULP1_YEAST ;
DR   Q0WKV8, ULP2A_ARATH;  Q8L7S0, ULP2B_ARATH;  O13769, ULP2_SCHPO ;
DR   P40537, ULP2_YEAST ;
//