ENZYME entry: EC 3.4.23.21

Accepted Name
Rhizopuspepsin.
Alternative Name(s)
Rhizopus aspartic proteinase.
Reaction catalysed
Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin
Comment(s)
From the zygomycete fungi Rhizopus chinensis and R.niveus. Belongs to peptidase family A1. Formerly EC 3.4.4.17, EC 3.4.23.6, EC 3.4.23.9 and EC 3.4.99.25.
Cross-references
PROSITE	PDOC00128
BRENDA	3.4.23.21
EC2PDB	3.4.23.21
ExplorEnz	3.4.23.21
PRIAM enzyme-specific profiles	3.4.23.21
KEGG Ligand Database for Enzyme Nomenclature	3.4.23.21
IUBMB Enzyme Nomenclature	3.4.23.21
IntEnz	3.4.23.21
MEDLINE	Find literature relating to 3.4.23.21
MetaCyc	3.4.23.21
UniProtKB/Swiss-Prot	P10602, CARP1_RHINI;   P43231, CARP2_RHINI;   Q03699, CARP3_RHINI;   Q03700, CARP4_RHINI;   P43232, CARP5_RHINI;   P06026, CARP_RHICH;

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