ID 3.4.23.28 DE acrocylindropepsin. AN Acrocylindrium proteinase. CA Preference for hydrophobic residue at P1 and P1'. Action on the B chain CA of insulin is generally similar to that of pepsin A, but it also cleaves CA 6-Leu-|-Cys(SO3H)-7, 21-Glu-|-Arg-22 and 3-Asn-|-Gln-4, although not CA 4-Gln-|-His-5. CC -!- From the imperfect fungus Acrocylindrium sp. CC -!- Has a very low pH optimum on casein of 2.0. CC -!- Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.99.1. //