ID   3.4.23.45
DE   memapsin 1.
AN   ASP1.
AN   BACE2.
AN   beta-secretase.
AN   beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2.
AN   beta-site APP-cleaving enzyme 2.
AN   Down region aspartic protease.
AN   membrane-associated aspartic protease 1.
CA   Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-
CA   Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
CC   -!- Can cleave beta-amyloid precursor protein to form the amyloidogenic
CC       beta-peptide that is implicated in the pathology of Alzheimer's
CC       disease, but is not significantly expressed in human brain.
CC   -!- Belongs to peptidase family A1.
DR   Q9Y5Z0, BACE2_HUMAN;  Q9JL18, BACE2_MOUSE;  Q6IE75, BACE2_RAT  ;
//