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ENZYME entry: EC 3.4.24.16

Accepted Name
Neurolysin.
Alternative Name(s)
Neurotensin endopeptidase.
Reaction catalysed
Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11
Cofactor(s)
Zn(2+).
Comment(s)
  • No absolute requirement for a prolyl bond; the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do.
  • Belongs to peptidase family M3.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.16
EC2PDB3.4.24.16
ExplorEnz3.4.24.16
PRIAM enzyme-specific profiles3.4.24.16
KEGG Ligand Database for Enzyme Nomenclature3.4.24.16
IUBMB Enzyme Nomenclature3.4.24.16
IntEnz3.4.24.16
MEDLINEFind literature relating to 3.4.24.16
MetaCyc3.4.24.16
UniProtKB/Swiss-Prot
A2VDQ5, NEUL_BOVIN;  Q9BYT8, NEUL_HUMAN;  Q91YP2, NEUL_MOUSE;  
Q02038, NEUL_PIG;  Q5R9V6, NEUL_PONAB;  P42675, NEUL_RABIT;  
P42676, NEUL_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.24.-
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