ENZYME entry: EC 3.4.24.17

Accepted Name
Stromelysin 1.
Alternative Name(s)
Matrix metalloproteinase 3.
Proteoglycanase.
Transin.
Reaction catalysed
Preferential cleavage where P1', P2' and P3' are hydrophobic residues
Cofactor(s)
Ca(2+); Zn(2+).
Comment(s)
  • Extracellular endopeptidase of vertebrate tissues.
  • Degradation of proteoglycans, fibronectin, collagen type III, IV, V and IX and activates procollagenase.
  • Belongs to peptidase family M10B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.17
EC2PDB3.4.24.17
ExplorEnz3.4.24.17
PRIAM enzyme-specific profiles3.4.24.17
KEGG Ligand Database for Enzyme Nomenclature3.4.24.17
IUBMB Enzyme Nomenclature3.4.24.17
IntEnz3.4.24.17
MEDLINEFind literature relating to 3.4.24.17
MetaCyc3.4.24.17
UniProtKB/Swiss-Prot
Q6Y4Q5, MMP3_CANLF;  Q28397, MMP3_HORSE;  P08254, MMP3_HUMAN;  
P28862, MMP3_MOUSE;  P28863, MMP3_RABIT;  P03957, MMP3_RAT;  

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