ENZYME entry: EC 3.4.24.21

Accepted Name
Astacin.
Alternative Name(s)
Astacus proteinase.
Crayfish small-molecule proteinase.
Reaction catalysed
Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'
Cofactor(s)
Zn(2+).
Comment(s)
  • A digestive endopeptidase from the cardia of the crayfish Astacus fluviatilis.
  • Belongs to peptidase family M12A.
  • Formerly EC 3.4.99.6.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.21
EC2PDB3.4.24.21
ExplorEnz3.4.24.21
PRIAM enzyme-specific profiles3.4.24.21
KEGG Ligand Database for Enzyme Nomenclature3.4.24.21
IUBMB Enzyme Nomenclature3.4.24.21
IntEnz3.4.24.21
MEDLINEFind literature relating to 3.4.24.21
MetaCyc3.4.24.21
UniProtKB/Swiss-Prot
P07584, ASTA_ASTAS;  Q21388, NAS10_CAEEL;  Q21432, NAS11_CAEEL;  
Q9XTD6, NAS12_CAEEL;  Q20191, NAS13_CAEEL;  Q19269, NAS14_CAEEL;  
P55115, NAS15_CAEEL;  Q21180, NAS16_CAEEL;  Q21178, NAS17_CAEEL;  
Q21179, NAS18_CAEEL;  Q21181, NAS19_CAEEL;  O62243, NAS1_CAEEL;  
Q22396, NAS20_CAEEL;  Q22398, NAS22_CAEEL;  Q7Z0M7, NAS23_CAEEL;  
Q93542, NAS24_CAEEL;  Q20459, NAS25_CAEEL;  Q22710, NAS26_CAEEL;  
O17264, NAS27_CAEEL;  P98061, NAS28_CAEEL;  Q20958, NAS29_CAEEL;  
Q9N5R0, NAS2_CAEEL;  Q9N2V2, NAS30_CAEEL;  Q7JLI1, NAS31_CAEEL;  
O16977, NAS32_CAEEL;  P55114, NAS33_CAEEL;  Q21059, NAS34_CAEEL;  
P98060, NAS35_CAEEL;  Q61EX6, NAS36_CAEBR;  Q18206, NAS36_CAEEL;  
Q93243, NAS37_CAEEL;  Q20942, NAS38_CAEEL;  Q20176, NAS39_CAEEL;  
Q21252, NAS3_CAEEL;  P55112, NAS4_CAEEL;  P91828, NAS5_CAEEL;  
Q9U3S9, NAS6_CAEEL;  P55113, NAS7_CAEEL;  Q18439, NAS8_CAEEL;  
P91137, NAS9_CAEEL;  

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