ENZYME entry: EC 3.4.24.26

Accepted Name
Pseudolysin.
Alternative Name(s)
Pseudomonas aeruginosa neutral metalloproteinase.
Pseudomonas elastase.
Reaction catalysed
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects
Cofactor(s)
Ca(2+); Zn(2+).
Comment(s)
  • Causes tissue damage.
  • Belongs to peptidase family M4.
  • Formerly EC 3.4.24.4.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.26
EC2PDB3.4.24.26
ExplorEnz3.4.24.26
PRIAM enzyme-specific profiles3.4.24.26
KEGG Ligand Database for Enzyme Nomenclature3.4.24.26
IUBMB Enzyme Nomenclature3.4.24.26
IntEnz3.4.24.26
MEDLINEFind literature relating to 3.4.24.26
MetaCyc3.4.24.26
UniProtKB/Swiss-Prot
Q02RJ6, ELAS_PSEAB;  P14756, ELAS_PSEAE;  

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