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ENZYME entry: EC 3.4.24.29

Accepted Name
Aureolysin.
Alternative Name(s)
Staphylococcus aureus neutral proteinase.
Reaction catalysed
Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residues. Activates the glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus
Cofactor(s)
Ca(2+); Zn(2+).
Comment(s)
  • Earlier confused with staphylokinase.
  • Belongs to peptidase family M4.
  • Formerly EC 3.4.24.4 and EC 3.4.99.22.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.29
EC2PDB3.4.24.29
ExplorEnz3.4.24.29
PRIAM enzyme-specific profiles3.4.24.29
KEGG Ligand Database for Enzyme Nomenclature3.4.24.29
IUBMB Enzyme Nomenclature3.4.24.29
IntEnz3.4.24.29
MEDLINEFind literature relating to 3.4.24.29
MetaCyc3.4.24.29
UniProtKB/Swiss-Prot
P81177, AURE_STAAU

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