ENZYME entry: EC 3.4.24.34

Accepted Name
Neutrophil collagenase.
Alternative Name(s)
Matrix metalloproteinase 8.
Reaction catalysed
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I
Cofactor(s)
Ca(2+); Zn(2+).
Comment(s)
  • Similar to interstitial collagenase in specificity.
  • Stored in the specific granules of neutrophil leukocytes.
  • Belongs to peptidase family M10B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.34
EC2PDB3.4.24.34
ExplorEnz3.4.24.34
PRIAM enzyme-specific profiles3.4.24.34
KEGG Ligand Database for Enzyme Nomenclature3.4.24.34
IUBMB Enzyme Nomenclature3.4.24.34
IntEnz3.4.24.34
MEDLINEFind literature relating to 3.4.24.34
MetaCyc3.4.24.34
UniProtKB/Swiss-Prot
P22894, MMP8_HUMAN;  O70138, MMP8_MOUSE;  O88766, MMP8_RAT;  

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