ID   3.4.24.36
DE   leishmanolysin.
AN   glycoprotein gp63.
AN   promastigote surface endopeptidase.
CA   Preference for hydrophobic residues at P1 and P1' and basic residues at
CA   P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.
CC   -!- A membrane-bound glycoprotein found on the promastigote of various
CC       species of Leishmania protozoans.
CC   -!- Contains consensus sequence for a zinc binding site; Z-Tyr-Leu-NHOH
CC       is a strong inhibitor.
CC   -!- The enzyme can activate its proenzyme by cleavage of the 100-
CC       Val-|-Val-101 bond.
CC   -!- An acidic pH optimum is found with certain protein substrates.
CC   -!- Belongs to peptidase family M8.
DR   Q06031, GP63_CRIFA ;  Q27673, GP63_LEIAM ;  P15706, GP63_LEICH ;
DR   P23223, GP63_LEIDO ;  Q00689, GP63_LEIGU ;  P08148, GP63_LEIMA ;
DR   P43150, GP63_LEIME ;  Q8MNZ1, GP63_LEITR ;
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