ENZYME entry: EC 3.4.24.39

Accepted Name
Deuterolysin.
Alternative Name(s)
Acid metalloproteinase.
Microbial neutral proteinase II.
Penicillium roqueforti protease II.
Reaction catalysed
Preferential cleavage of bonds with hydrophobic residues in P1'; also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain
Cofactor(s)
Zinc.
Comment(s)
  • Proteolytic activity found in Penicillium roqueforti, P.caseicolum, Aspergillus sojae and A.oryzae.
  • Optimum pH of 5 for digesting various proteins.
  • Strong action on protamine and histones.
  • Insensitive to phosphoramidon.
  • A distinct A.sojae endopeptidase is larger and has neutral pH optimum.
  • Belongs to peptidase family M35.
  • Formerly EC 3.4.24.4.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.39
EC2PDB3.4.24.39
ExplorEnz3.4.24.39
PRIAM enzyme-specific profiles3.4.24.39
KEGG Ligand Database for Enzyme Nomenclature3.4.24.39
IUBMB Enzyme Nomenclature3.4.24.39
IntEnz3.4.24.39
MEDLINEFind literature relating to 3.4.24.39
MetaCyc3.4.24.39
UniProtKB/Swiss-Prot
P46073, MEP20_ASPFL;  Q09016, MEP20_ASPFM;  C5PE62, MEP2_COCP7;  
C5P507, MEP3_COCP7;  C5PIJ9, MEP4_COCP7;  C5NZY5, MEP5_COCP7;  
C5PE18, MEP6_COCP7;  C5P3T4, MEP7_COCP7;  C5NZL6, MEP8_COCP7;  
C5G8P3, NPIIA_AJEDR;  C5JKQ0, NPIIA_AJEDS;  E4UUX3, NPIIA_ARTGP;  
C5FR79, NPIIA_ARTOC;  A1CIU4, NPIIA_ASPCL;  B0YEV0, NPIIA_ASPFC;  
B8NJB2, NPIIA_ASPFN;  Q4WQR6, NPIIA_ASPFU;  Q2UP30, NPIIA_ASPOR;  
Q0CMZ3, NPIIA_ASPTN;  A6SBW7, NPIIA_BOTFB;  E3QWD3, NPIIA_COLGM;  
Q5AUR8, NPIIA_EMENI;  Q2KH28, NPIIA_MAGO7;  A1DA48, NPIIA_NEOFI;  
C1G1N6, NPIIA_PARBD;  C0S3U8, NPIIA_PARBP;  Q0UCJ2, NPIIA_PHANO;  
A7F811, NPIIA_SCLS1;  C0IPP1, NPIIA_TRIRU;  C4JLQ3, NPIIA_UNCRE;  
C5JHY1, NPIIB_AJEDS;  D4ANL2, NPIIB_ARTBC;  E5R1Z3, NPIIB_ARTGP;  
C5FCA7, NPIIB_ARTOC;  B0Y4X9, NPIIB_ASPFC;  B8NWE1, NPIIB_ASPFN;  
Q5B7T7, NPIIB_EMENI;  A1CVX6, NPIIB_NEOFI;  Q0V1D7, NPIIB_PHANO;  
C0IPP2, NPIIB_TRIRU;  D4DE03, NPIIB_TRIVH;  C4JK49, NPIIB_UNCRE;  
D4AM79, NPIIC_ARTBC;  E4UR63, NPIIC_ARTGP;  C5FPC2, NPIIC_ARTOC;  
Q4WA45, NPIIC_ASPFU;  D4DGR5, NPIIC_TRIVH;  C4JH04, NPIIC_UNCRE;  
D4B639, NPIID_ARTBC;  E4US45, NPIID_ARTGP;  C5FWQ2, NPIID_ARTOC;  
D4D616, NPIID_TRIVH;  D4AXC1, NPIIE_ARTBC;  C5FIT1, NPIIE_ARTOC;  
D4AJ87, NPIIF_ARTBC;  E4UYQ9, NPIIF_ARTGP;  D4D7X4, NPIIF_TRIVH;  
P46076, NPII_ASPOR;  P47189, PLNC_PENCI;  

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