ENZYME entry: EC 3.4.24.40
| Accepted Name |
|---|
| Serralysin.
|
| Alternative Name(s) |
|---|
| Escherichia freundii proteinase. |
| Pseudomonas aeruginosa alkaline protease. |
| Serratia marcescens extracellular proteinase. |
| Reaction catalysed |
|---|
| Preferential cleavage of bonds with hydrophobic residues in P1' |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- An extracellular endopeptidase from Pseudomonas aeruginosa,
Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi.
- There is broad specificity in cleavage of the insulin B chain, with
some species variations.
- The pH optimum for digesting various proteins is about 9-10.
- Belongs to peptidase family M10A.
- Formerly EC 3.4.24.4.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.40 |
| EC2PDB | 3.4.24.40 |
| ExplorEnz | 3.4.24.40 |
| PRIAM enzyme-specific profiles | 3.4.24.40 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.40 |
| IUBMB Enzyme Nomenclature | 3.4.24.40 |
| IntEnz | 3.4.24.40 |
| MEDLINE | Find literature relating to 3.4.24.40 |
| MetaCyc | 3.4.24.40 |
| UniProtKB/Swiss-Prot |
| Q03023, APRA_PSEAE; | Q84F70, PRTA1_PHOLU; | Q07295, PRTA_ERWCH; |
| P82115, PRTA_PHOAZ; | Q7N8R3, PRTA_PHOLL; | P16316, PRTB_ERWCH; |
| P16317, PRTC_ERWCH; | Q07162, PRTG_ERWCH; | P19144, PRTX_ERWCH; |
| P23694, PRZN_SERMA; | P07268, PRZN_SERME; | Q11137, ZAPA_PROMI; |
|
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