ENZYME entry: EC 3.4.24.40

Accepted Name
Serralysin.
Alternative Name(s)
Escherichia freundii proteinase.
Pseudomonas aeruginosa alkaline protease.
Serratia marcescens extracellular proteinase.
Reaction catalysed
Preferential cleavage of bonds with hydrophobic residues in P1'
Cofactor(s)
Zinc.
Comment(s)
  • An extracellular endopeptidase from Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi.
  • There is broad specificity in cleavage of the insulin B chain, with some species variations.
  • The pH optimum for digesting various proteins is about 9-10.
  • Belongs to peptidase family M10A.
  • Formerly EC 3.4.24.4.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.40
EC2PDB3.4.24.40
ExplorEnz3.4.24.40
PRIAM enzyme-specific profiles3.4.24.40
KEGG Ligand Database for Enzyme Nomenclature3.4.24.40
IUBMB Enzyme Nomenclature3.4.24.40
IntEnz3.4.24.40
MEDLINEFind literature relating to 3.4.24.40
MetaCyc3.4.24.40
UniProtKB/Swiss-Prot
Q03023, APRA_PSEAE;  Q84F70, PRTA1_PHOLU;  Q07295, PRTA_DICCH;  
P82115, PRTA_PHOAZ;  Q7N8R3, PRTA_PHOLL;  P16316, PRTB_DICCH;  
P16317, PRTC_DICCH;  Q07162, PRTG_DICCH;  P19144, PRTX_DICCH;  
P23694, PRZN_SERMA;  P07268, PRZN_SERME;  Q11137, ZAPA_PROMI;  

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