ENZYME entry: EC 3.4.24.44
| Accepted Name |
|---|
| Atrolysin E.
|
| Alternative Name(s) |
|---|
| Crotalus atrox metalloendopeptidase e. |
| Hemorrhagic toxin e. |
| Reaction catalysed |
|---|
| Cleavage of 3-Asn-|-Gln-4, 9-Ser-|-His-10 and 14-Ala-|-Leu-15 bonds in insulin B chain and 14-Tyr-|-Gln-15 and 8-Thr-|-Ser-9 in A chain. Cleaves type IV collagen at 73-Ala-|-Gln-74 in alpha-1-(IV) and at 7-Gly-|-Leu-8 in alpha-2-(IV) |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Hemorrhagic endopeptidase from the venom of the western diamondback
rattlesnake (Crotalus atrox).
- Digests basement membrane components, including the triple helix of
type IV collagen.
- Such action is believed to contribute to the hemorrhagic property by
weakening capillary walls.
- Belongs to peptidase family M12B.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.44 |
| EC2PDB | 3.4.24.44 |
| ExplorEnz | 3.4.24.44 |
| PRIAM enzyme-specific profiles | 3.4.24.44 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.44 |
| IUBMB Enzyme Nomenclature | 3.4.24.44 |
| IntEnz | 3.4.24.44 |
| MEDLINE | Find literature relating to 3.4.24.44 |
| MetaCyc | 3.4.24.44 |
| UniProtKB/Swiss-Prot |
|
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