ID   3.4.24.44
DE   atrolysin E.
AN   Crotalus atrox metalloendopeptidase e.
AN   hemorrhagic toxin e.
CA   Cleavage of 3-Asn-|-Gln-4, 9-Ser-|-His-10 and 14-Ala-|-Leu-15 bonds in
CA   insulin B chain and 14-Tyr-|-Gln-15 and 8-Thr-|-Ser-9 in A chain. Cleaves
CA   type IV collagen at 73-Ala-|-Gln-74 in alpha1-(IV) and at 7-Gly-|-Leu-8
CA   in alpha2-(IV).
CC   -!- Hemorrhagic endopeptidase from the venom of the western diamondback
CC       rattlesnake (Crotalus atrox).
CC   -!- Digests basement membrane components, including the triple helix of
CC       type IV collagen.
CC   -!- Such action is believed to contribute to the hemorrhagic property by
CC       weakening capillary walls.
CC   -!- Belongs to peptidase family M12B.
DR   P34182, VM2AE_CROAT;
//