ENZYME entry: EC 3.4.24.46

Accepted Name
Adamalysin.
Alternative Name(s)
Crotalus adamanteus metalloendopeptidase.
Proteinase I and II.
Reaction catalysed
Cleavage of 1-Phe-|-Val-2, 5-His-|-Leu-6, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, and 16-Tyr-|-Leu-17 of insulin B chain
Cofactor(s)
Zn(2+).
Comment(s)
  • From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus).
  • Two isoenzymes of approximately 24 kDa that inactivate alpha-1- proteinase inhibitor by a single cleavage.
  • Belongs to peptidase family M12B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.46
EC2PDB3.4.24.46
ExplorEnz3.4.24.46
PRIAM enzyme-specific profiles3.4.24.46
KEGG Ligand Database for Enzyme Nomenclature3.4.24.46
IUBMB Enzyme Nomenclature3.4.24.46
IntEnz3.4.24.46
MEDLINEFind literature relating to 3.4.24.46
MetaCyc3.4.24.46
UniProtKB/Swiss-Prot
P34179, VM12_CROAD

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