ENZYME entry: EC 3.4.24.46
| Accepted Name |
|---|
| Adamalysin.
|
| Alternative Name(s) |
|---|
| Crotalus adamanteus metalloendopeptidase. |
| Proteinase I and II. |
| Reaction catalysed |
|---|
| Cleavage of 1-Phe-|-Val-2, 5-His-|-Leu-6, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, and 16-Tyr-|-Leu-17 of insulin B chain |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- From the venom of the eastern diamondback rattlesnake (Crotalus
adamanteus).
- Two isoenzymes of approximately 24 kDa that inactivate alpha-1-
proteinase inhibitor by a single cleavage.
- Belongs to peptidase family M12B.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.46 |
| EC2PDB | 3.4.24.46 |
| ExplorEnz | 3.4.24.46 |
| PRIAM enzyme-specific profiles | 3.4.24.46 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.46 |
| IUBMB Enzyme Nomenclature | 3.4.24.46 |
| IntEnz | 3.4.24.46 |
| MEDLINE | Find literature relating to 3.4.24.46 |
| MetaCyc | 3.4.24.46 |
| UniProtKB/Swiss-Prot |
|
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