ENZYME entry: EC 3.4.24.47

Accepted Name
Horrilysin.
Alternative Name(s)
Crotalus horridus metalloendopeptidase.
Hemorrhagic proteinase IV.
Reaction catalysed
Cleavage of only the single bond 14-Ala-|-Leu-15 in the insulin B chain, 12-Ser-|-Leu-13 in the A chain, and Ile-|-Gly, Pro-|-Ala, and Ser-|-Trp in mellitin
Cofactor(s)
Zn(2+).
Comment(s)
  • Cleaves basement membrane, hide powder and fibrinogen.
  • Hemorrhagic endopeptidase from the venom of the timber rattlesnake (Crotalus horridus horridus).
  • Belongs to peptidase family M12B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.47
EC2PDB3.4.24.47
ExplorEnz3.4.24.47
PRIAM enzyme-specific profiles3.4.24.47
KEGG Ligand Database for Enzyme Nomenclature3.4.24.47
IUBMB Enzyme Nomenclature3.4.24.47
IntEnz3.4.24.47
MEDLINEFind literature relating to 3.4.24.47
MetaCyc3.4.24.47

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