ENZYME entry: EC 3.4.24.48
| Accepted Name |
|---|
| Ruberlysin.
|
| Alternative Name(s) |
|---|
| Crotalus ruber metalloendopeptidase II. |
| Hemorrhagic metalloproteinase HT-2. |
| Hemorrhagic toxin II. |
| Reaction catalysed |
|---|
| Cleavage of 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and 23-Gly-|-Phe-24 bonds of the B chain of insulin; His-|-Pro, Pro-|-Phe, and Trp-|-Ser of angiotensin I; and Gly-|-Phe of Met enkephalin |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Hemorrhagic endopeptidase from the venom of the red rattlesnake
(Crotalus ruber ruber).
- Cleaves fibrinogen.
- Belongs to peptidase family M12B.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.48 |
| EC2PDB | 3.4.24.48 |
| ExplorEnz | 3.4.24.48 |
| PRIAM enzyme-specific profiles | 3.4.24.48 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.48 |
| IUBMB Enzyme Nomenclature | 3.4.24.48 |
| IntEnz | 3.4.24.48 |
| MEDLINE | Find literature relating to 3.4.24.48 |
| MetaCyc | 3.4.24.48 |
| UniProtKB/Swiss-Prot |
|
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