ENZYME entry: EC 3.4.24.50

Accepted Name
Bothrolysin.
Alternative Name(s)
Bothrops metalloendopeptidase J.
J protease.
Reaction catalysed
Cleavage of 4-Gln-|-His-5, 9-Ser-|-His-10 and 14-Ala-|-Leu-15 of insulin B chain and Pro-|-Phe of angiotensin I
Cofactor(s)
Zn(2+).
Comment(s)
  • Endopeptidase from the venom of the jararaca snake (Bothrops jararaca).
  • Insensitive to phosphoramidon at 0.5 mM.
  • Belongs to peptidase family M12B.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.50
EC2PDB3.4.24.50
ExplorEnz3.4.24.50
PRIAM enzyme-specific profiles3.4.24.50
KEGG Ligand Database for Enzyme Nomenclature3.4.24.50
IUBMB Enzyme Nomenclature3.4.24.50
IntEnz3.4.24.50
MEDLINEFind literature relating to 3.4.24.50
MetaCyc3.4.24.50
UniProtKB/Swiss-Prot
P20416, VMXBN_BOTJA

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