ENZYME entry: EC 3.4.24.60

Accepted Name
Dactylysin.
Alternative Name(s)
Peptide hormone inactivating endopeptidase.
Reaction catalysed
Hydrolysis of peptides of at least six residues, with bulky hydrophobic residues in the P1' position. Shows a preference for hydrophobic doublets such as -Phe-|-Phe- and -Phe-|-Leu- in somatostatin-(1-14)-peptide and dynorphin A-(1-6)-peptide, respectively
Comment(s)
  • An endopeptidase of 100 kDa secreted from the skin of Xenopus laevis.
  • Resembles neprilysin in insensitivity to 1 uM captopril, but differs in being insensitive to thiorphan and unable to digest (5-Met)- enkephalin, (5-Leu)-enkephalin, oxytocin and substance P-(7-11)- peptide.
Cross-references
BRENDA3.4.24.60
EC2PDB3.4.24.60
ExplorEnz3.4.24.60
PRIAM enzyme-specific profiles3.4.24.60
KEGG Ligand Database for Enzyme Nomenclature3.4.24.60
IUBMB Enzyme Nomenclature3.4.24.60
IntEnz3.4.24.60
MEDLINEFind literature relating to 3.4.24.60
MetaCyc3.4.24.60

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