ENZYME entry: EC 3.4.24.74

Accepted Name
Fragilysin.
Alternative Name(s)
Bacteroides fragilis enterotoxin.
Reaction catalysed
Broad proteolytic specificity, bonds hydrolyzed includes -Gly-|-Leu-, -Met-|-Leu-, -Phe-|-Leu-, -Cys-|-Leu-, -Leu-|-Gly-
Cofactor(s)
Zinc.
Comment(s)
  • Thought to be a cause of diarrhea.
  • Hydrolyzes extracellular matrix proteins, and disrupts tight junctions of intstinal cells.
  • Also degrades intracellular, cytoskeletal proteins actin, myosin and others.
  • Belongs to peptidase family M10.
Cross-references
BRENDA3.4.24.74
EC2PDB3.4.24.74
ExplorEnz3.4.24.74
PRIAM enzyme-specific profiles3.4.24.74
KEGG Ligand Database for Enzyme Nomenclature3.4.24.74
IUBMB Enzyme Nomenclature3.4.24.74
IntEnz3.4.24.74
MEDLINEFind literature relating to 3.4.24.74
MetaCyc3.4.24.74
UniProtKB/Swiss-Prot
P54355, ENTM_BACFG

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