ENZYME entry: EC 3.4.24.74
| Accepted Name |
|---|
| Fragilysin.
|
| Alternative Name(s) |
|---|
| Bacteroides fragilis enterotoxin. |
| Reaction catalysed |
|---|
| Broad proteolytic specificity, bonds hydrolyzed includes -Gly-|-Leu-, -Met-|-Leu-, -Phe-|-Leu-, -Cys-|-Leu-, -Leu-|-Gly- |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Thought to be a cause of diarrhea.
- Hydrolyzes extracellular matrix proteins, and disrupts tight
junctions of intstinal cells.
- Also degrades intracellular, cytoskeletal proteins actin, myosin and
others.
- Belongs to peptidase family M10.
|
| Cross-references |
|---|
| BRENDA | 3.4.24.74 |
| EC2PDB | 3.4.24.74 |
| ExplorEnz | 3.4.24.74 |
| PRIAM enzyme-specific profiles | 3.4.24.74 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.74 |
| IUBMB Enzyme Nomenclature | 3.4.24.74 |
| IntEnz | 3.4.24.74 |
| MEDLINE | Find literature relating to 3.4.24.74 |
| MetaCyc | 3.4.24.74 |
| UniProtKB/Swiss-Prot |
|
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