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ENZYME entry: EC 220.127.116.11
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|Insulin-like growth factor binding protein-4 protease.|
|Pregnancy-associated plasma protein-A.|
|Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5|
- Circulates in human pregnancy mainly as a complex with the proform of
eosinophil major basic protein, which acts as an inhibitor of the
- The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the
presence of insulin-like growth factor (IGF), whereas that of IGFBP-5
is decreased about two-fold.
- Belongs to peptidase family M43.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
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