ENZYME entry: EC 3.4.24.79
| Accepted Name |
|---|
| Pappalysin-1.
|
| Alternative Name(s) |
|---|
| Insulin-like growth factor binding protein-4 protease. |
| Pregnancy-associated plasma protein-A. |
| Reaction catalysed |
|---|
| Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5 |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Circulates in human pregnancy mainly as a complex with the proform of
eosinophil major basic protein, which acts as an inhibitor of the
peptidase.
- The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the
presence of insulin-like growth factor (IGF), whereas that of IGFBP-5
is decreased about two-fold.
- Belongs to peptidase family M43.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.79 |
| EC2PDB | 3.4.24.79 |
| ExplorEnz | 3.4.24.79 |
| PRIAM enzyme-specific profiles | 3.4.24.79 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.79 |
| IUBMB Enzyme Nomenclature | 3.4.24.79 |
| IntEnz | 3.4.24.79 |
| MEDLINE | Find literature relating to 3.4.24.79 |
| MetaCyc | 3.4.24.79 |
| UniProtKB/Swiss-Prot |
|
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