ENZYME entry: EC 3.4.24.79

Accepted Name
Pappalysin-1.
Alternative Name(s)
Insulin-like growth factor binding protein-4 protease.
Pregnancy-associated plasma protein-A.
Reaction catalysed
Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5
Cofactor(s)
Zinc.
Comment(s)
  • Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase.
  • The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold.
  • Belongs to peptidase family M43.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.79
EC2PDB3.4.24.79
ExplorEnz3.4.24.79
PRIAM enzyme-specific profiles3.4.24.79
KEGG Ligand Database for Enzyme Nomenclature3.4.24.79
IUBMB Enzyme Nomenclature3.4.24.79
IntEnz3.4.24.79
MEDLINEFind literature relating to 3.4.24.79
MetaCyc3.4.24.79
UniProtKB/Swiss-Prot
Q13219, PAPP1_HUMAN;  Q8R4K8, PAPP1_MOUSE;  

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