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ENZYME

ENZYME entry: EC 3.4.24.81

Accepted Name
ADAM10 endopeptidase
Alternative Name(s)
Kuzbanian protein
myelin-associated disintegrin metalloproteinase
Reaction catalysed
Endopeptidase of broad specificity
Comment(s)
  • Partially responsible for the 'alpha-secretase' activity in brain that degrades the potentially harmful beta-amyloid peptide.
  • Work with ADAM10-deficient mice supports a role in Notch signaling.
  • Belongs to peptidase family M12.
Cross-references
BRENDA3.4.24.81
EC2PDB3.4.24.81
ExplorEnz3.4.24.81
PRIAM enzyme-specific profiles3.4.24.81
KEGG Ligand Database for Enzyme Nomenclature3.4.24.81
IUBMB Enzyme Nomenclature3.4.24.81
IntEnz3.4.24.81
MEDLINEFind literature relating to 3.4.24.81
MetaCyc3.4.24.81
Rhea expert-curated reactions3.4.24.81
UniProtKB/Swiss-Prot
Q10741, ADA10_BOVING5EFD9, ADA10_CAEELO14672, ADA10_HUMAN
O35598, ADA10_MOUSEO77633, ADA10_PIGQ10743, ADA10_RAT
Q8JIY1, ADA10_XENLA

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