ENZYME entry: EC 3.4.24.81
| Accepted Name |
|---|
| ADAM10 endopeptidase.
|
| Alternative Name(s) |
|---|
| Kuzbanian protein. |
| Myelin-associated disintegrin metalloproteinase. |
| Reaction catalysed |
|---|
| Endopeptidase of broad specificity |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Partially responsible for the 'alpha-secretase' activity in brain
that degrades the potentially harmful beta-amyloid peptide.
- Work with ADAM10-deficient mice supports a role in Notch signaling.
- Belongs to peptidase family M12.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.81 |
| EC2PDB | 3.4.24.81 |
| ExplorEnz | 3.4.24.81 |
| PRIAM enzyme-specific profiles | 3.4.24.81 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.81 |
| IUBMB Enzyme Nomenclature | 3.4.24.81 |
| IntEnz | 3.4.24.81 |
| MEDLINE | Find literature relating to 3.4.24.81 |
| MetaCyc | 3.4.24.81 |
| UniProtKB/Swiss-Prot |
|
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