ENZYME entry: EC 3.4.24.82

Accepted Name
ADAMTS-4 endopeptidase.
Alternative Name(s)
Aggrecanase-1.
Reaction catalysed
Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan
Cofactor(s)
Zn(2+).
Comment(s)
  • Thought to be biologically significant for the degradation of the aggrecan component of cartilage matrix.
  • Belongs to peptidase family M12.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.82
EC2PDB3.4.24.82
ExplorEnz3.4.24.82
PRIAM enzyme-specific profiles3.4.24.82
KEGG Ligand Database for Enzyme Nomenclature3.4.24.82
IUBMB Enzyme Nomenclature3.4.24.82
IntEnz3.4.24.82
MEDLINEFind literature relating to 3.4.24.82
MetaCyc3.4.24.82
UniProtKB/Swiss-Prot
Q9TT93, ATS4_BOVIN;  O75173, ATS4_HUMAN;  Q8BNJ2, ATS4_MOUSE;  
Q5RFQ8, ATS4_PONAB;  Q9ESP7, ATS4_RAT;  

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