ENZYME entry: EC 3.4.24.82
| Accepted Name |
|---|
| ADAMTS-4 endopeptidase.
|
| Alternative Name(s) |
|---|
| Aggrecanase-1. |
| Reaction catalysed |
|---|
| Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Thought to be biologically significant for the degradation of the
aggrecan component of cartilage matrix.
- Belongs to peptidase family M12.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.82 |
| EC2PDB | 3.4.24.82 |
| ExplorEnz | 3.4.24.82 |
| PRIAM enzyme-specific profiles | 3.4.24.82 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.82 |
| IUBMB Enzyme Nomenclature | 3.4.24.82 |
| IntEnz | 3.4.24.82 |
| MEDLINE | Find literature relating to 3.4.24.82 |
| MetaCyc | 3.4.24.82 |
| UniProtKB/Swiss-Prot |
|
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