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ENZYME entry: EC 3.4.24.83

Accepted Name
Anthrax lethal factor endopeptidase.
Alternative Name(s)
Lethal toxin.
Reaction catalysed
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases
Cofactor(s)
Zn(2+).
Comment(s)
  • From the bacterium Bacilus anthracis that causes anthrax.
  • One of three proteins that are collectively termed anthrax toxin.
  • Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases.
  • Belongs to peptidase family M34.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.83
EC2PDB3.4.24.83
ExplorEnz3.4.24.83
PRIAM enzyme-specific profiles3.4.24.83
KEGG Ligand Database for Enzyme Nomenclature3.4.24.83
IUBMB Enzyme Nomenclature3.4.24.83
IntEnz3.4.24.83
MEDLINEFind literature relating to 3.4.24.83
MetaCyc3.4.24.83
UniProtKB/Swiss-Prot
P15917, LEF_BACAN

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