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ENZYME entry: EC

Accepted Name
Anthrax lethal factor endopeptidase.
Alternative Name(s)
Lethal toxin.
Reaction catalysed
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases
  • From the bacterium Bacilus anthracis that causes anthrax.
  • One of three proteins that are collectively termed anthrax toxin.
  • Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases.
  • Belongs to peptidase family M34.
PRIAM enzyme-specific profiles3.4.24.83
KEGG Ligand Database for Enzyme Nomenclature3.4.24.83
IUBMB Enzyme Nomenclature3.4.24.83
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.24.-
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