ID   3.4.24.84
DE   Ste24 endopeptidase.
AN   CAAX prenyl protease 1.
AN   prenyl protein-specific endoprotease 1.
CA   Hydrolyzes the peptide bond -P2-(S-farnesyl or
CA   geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with
CA   aliphatic side chains and P3' is any C-terminal residue.
CC   -!- The enzyme hydrolyzes proteins that terminate with a CaaX motif in
CC       which C is an S-isoprenylated cysteine residue, a is usually
CC       aliphatic and X is the C-terminal residue of the substrate protein,
CC       and may be any of several amino acids.
CC   -!- The enzyme is one of two enzymes that can catalyze this processing
CC       step for mating a-factor in yeast.
CC   -!- Subsequently, the S-isoprenylated cysteine residue that forms the new
CC       C-terminus is methyl-esterified and forms a hydrophobic membrane-
CC       anchor.
CC   -!- Differs from EC 3.4.26.1 in its catalytic mechanism and substrate
CC       preference.
CC   -!- Belongs to peptidase family M48.
DR   Q8RX88, FACE1_ARATH;  Q9XVE5, FACE1_CAEEL;  Q54FH7, FACE1_DICDI;
DR   O75844, FACE1_HUMAN;  Q80W54, FACE1_MOUSE;  Q6EPN8, FACE1_ORYSJ;
DR   Q3Y6B8, FACE_TAESO ;  Q10071, STE24_SCHPO;  P47154, STE24_YEAST;
//