ENZYME entry: EC 3.4.24.86

Accepted Name
ADAM 17 endopeptidase.
Alternative Name(s)
TACE.
Tumor necrosis factor alpha-converting enzyme.
Reaction catalysed
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains
Cofactor(s)
Zinc.
Comment(s)
  • In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation.
  • Belongs to peptidase family M12.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.86
EC2PDB3.4.24.86
ExplorEnz3.4.24.86
PRIAM enzyme-specific profiles3.4.24.86
KEGG Ligand Database for Enzyme Nomenclature3.4.24.86
IUBMB Enzyme Nomenclature3.4.24.86
IntEnz3.4.24.86
MEDLINEFind literature relating to 3.4.24.86
MetaCyc3.4.24.86
UniProtKB/Swiss-Prot
P78536, ADA17_HUMAN;  Q9Z0F8, ADA17_MOUSE;  O77636, ADA17_PIG;  
Q9Z1K9, ADA17_RAT;  

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