ENZYME entry: EC 3.4.24.86
| Accepted Name |
|---|
| ADAM 17 endopeptidase.
|
| Alternative Name(s) |
|---|
| TACE. |
| Tumor necrosis factor alpha-converting enzyme. |
| Reaction catalysed |
|---|
| Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- In vivo, the cleavage of tumor necrosis factor alpha precursor
releases the soluble, 17-kDa TNF-alpha, which induces inflammation.
- Belongs to peptidase family M12.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.24.86 |
| EC2PDB | 3.4.24.86 |
| ExplorEnz | 3.4.24.86 |
| PRIAM enzyme-specific profiles | 3.4.24.86 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.24.86 |
| IUBMB Enzyme Nomenclature | 3.4.24.86 |
| IntEnz | 3.4.24.86 |
| MEDLINE | Find literature relating to 3.4.24.86 |
| MetaCyc | 3.4.24.86 |
| UniProtKB/Swiss-Prot |
|
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