ID 3.4.25.1 DE Proteasome endopeptidase complex. AN Ingensin. AN Lens neutral proteinase. AN Macropain. AN Multicatalytic endopeptidase complex. AN Multicatalytic proteinase (complex). AN Prosome. AN Proteasome. CA Cleavage of peptide bonds with very broad specificity. CC -!- A 20-S protein composed of 28 subunits arranged in four rings of CC seven. CC -!- The outer rings are composed of alpha subunits, but the beta subunits CC forming the inner rings are responsible for peptidase activity. CC -!- In eukaryotic organisms there are up to seven different types of beta CC subunits, three of which may carry the N-terminal threonine residues CC that are the nucleophiles in catalysis, and show different CC specificities. CC -!- The molecule is barrel-shaped, and the active sites are on the inner CC surfaces. CC -!- Terminal apertures restrict access of substrates to the active sites. CC -!- Inhibited by mercurial reagents and some inhibitors of serine CC endopeptidases. CC -!- Belongs to peptidase family T1. CC -!- Formerly EC 3.4.22.21, EC 3.4.24.5 and EC 3.4.99.46. PR PROSITE; PDOC00326; PR PROSITE; PDOC00668; DR A7KE01, PB6LA_SALSA; A7KII6, PB6LB_SALSA; P34066, PSA1A_ARATH; DR O23712, PSA1B_ARATH; Q3T0X5, PSA1_BOVIN ; O44156, PSA1_CAEEL ; DR O42265, PSA1_CHICK ; Q27562, PSA1_DICDI ; P12881, PSA1_DROME ; DR Q8SQS5, PSA1_ENCCU ; Q5V2X8, PSA1_HALMA ; Q9V2V6, PSA1_HALVD ; DR P25786, PSA1_HUMAN ; Q4R3H2, PSA1_MACFA ; Q9R1P4, PSA1_MOUSE ; DR P52428, PSA1_ORYSJ ; Q5REN2, PSA1_PONAB ; P18420, PSA1_RAT ; DR Q53080, PSA1_RHOER ; O14250, PSA1_SCHPO ; Q9GU37, PSA1_TRYBB ; DR O96788, PSA1_TRYBR ; P92188, PSA1_TRYCR ; P40302, PSA1_YEAST ; DR O23708, PSA2A_ARATH; Q8L4A7, PSA2B_ARATH; Q3T0Y5, PSA2_BOVIN ; DR Q27488, PSA2_CAEEL ; O73672, PSA2_CARAU ; Q54DM7, PSA2_DICDI ; DR P40301, PSA2_DROME ; Q5V1D4, PSA2_HALMA ; Q9V2V5, PSA2_HALVD ; DR P25787, PSA2_HUMAN ; P49722, PSA2_MOUSE ; Q8X077, PSA2_NEUCR ; DR A2YVR7, PSA2_ORYSI ; Q10KF0, PSA2_ORYSJ ; P17220, PSA2_RAT ; DR Q53084, PSA2_RHOER ; O94579, PSA2_SCHPO ; Q9U793, PSA2_TRYBB ; DR P24495, PSA2_XENLA ; P23639, PSA2_YEAST ; P90513, PSA3_ACACA ; DR O23715, PSA3_ARATH ; Q58DU5, PSA3_BOVIN ; Q09583, PSA3_CAEEL ; DR Q27563, PSA3_DICDI ; Q9V5C6, PSA3_DROME ; Q8SQP9, PSA3_ENCCU ; DR P25788, PSA3_HUMAN ; O70435, PSA3_MOUSE ; Q9LSU0, PSA3_ORYSJ ; DR P18422, PSA3_RAT ; O59770, PSA3_SCHPO ; O24362, PSA3_SPIOL ; DR P21242, PSA3_YEAST ; A2Y9X7, PSA4A_ORYSI; P0C1G8, PSA4A_ORYSJ; DR P0C8Y9, PSA4B_ORYSI; Q5VRG3, PSA4B_ORYSJ; Q9VA12, PSA4L_DROME; DR O81148, PSA4_ARATH ; Q3ZCK9, PSA4_BOVIN ; Q9N599, PSA4_CAEEL ; DR P34119, PSA4_DICDI ; P18053, PSA4_DROME ; Q8SRU7, PSA4_ENCCU ; DR P25789, PSA4_HUMAN ; Q4R932, PSA4_MACFA ; Q9R1P0, PSA4_MOUSE ; DR O82530, PSA4_PETHY ; P21670, PSA4_RAT ; Q09682, PSA4_SCHPO ; DR P52427, PSA4_SPIOL ; P23638, PSA4_YEAST ; O81149, PSA5A_ARATH; DR Q42134, PSA5B_ARATH; Q5E987, PSA5_BOVIN ; Q95008, PSA5_CAEEL ; DR Q55G04, PSA5_DICDI ; Q95083, PSA5_DROME ; Q8SRU3, PSA5_ENCCU ; DR Q94561, PSA5_ENTHI ; P28066, PSA5_HUMAN ; Q9Z2U1, PSA5_MOUSE ; DR Q9LSU1, PSA5_ORYSJ ; P34064, PSA5_RAT ; Q9UT97, PSA5_SCHPO ; DR Q9M4T8, PSA5_SOYBN ; Q9XZG5, PSA5_TRYBB ; P32379, PSA5_YEAST ; DR O81146, PSA6A_ARATH; O81147, PSA6B_ARATH; Q2YDE4, PSA6_BOVIN ; DR O17586, PSA6_CAEEL ; Q54XM7, PSA6_DICDI ; Q9XZJ4, PSA6_DROME ; DR P60900, PSA6_HUMAN ; Q9QUM9, PSA6_MOUSE ; Q9LSU3, PSA6_ORYSJ ; DR P60901, PSA6_RAT ; O94517, PSA6_SCHPO ; O48551, PSA6_SOYBN ; DR Q9XG77, PSA6_TOBAC ; P21243, PSA6_YEAST ; P22769, PSA71_DROME; DR O16811, PSA71_DROVI; Q24178, PSA72_DROME; Q27575, PSA73_DROME; DR O16812, PSA73_DROVI; P30186, PSA7A_ARATH; A2YXU2, PSA7A_ORYSI; DR Q6YT00, PSA7A_ORYSJ; Q9PVY6, PSA7A_XENLA; O24616, PSA7B_ARATH; DR A2Z3I9, PSA7B_ORYSI; Q0J006, PSA7B_ORYSJ; Q9PVQ1, PSA7B_XENLA; DR Q8TAA3, PSA7L_HUMAN; Q4R7D9, PSA7L_MACFA; Q9CWH6, PSA7L_MOUSE; DR Q3ZBG0, PSA7_BOVIN ; Q95005, PSA7_CAEEL ; Q9PTW9, PSA7_CARAU ; DR O13268, PSA7_CHICK ; Q9SXU1, PSA7_CICAR ; P34120, PSA7_DICDI ; DR O14818, PSA7_HUMAN ; Q9Z2U0, PSA7_MOUSE ; Q5RDH8, PSA7_PONAB ; DR P48004, PSA7_RAT ; Q10329, PSA7_SCHPO ; O24030, PSA7_SOLLC ; DR Q9NDA2, PSA7_TRYBB ; P40303, PSA7_YEAST ; A0LU51, PSA_ACIC1 ; DR C7LYP8, PSA_ACIFD ; C6WID9, PSA_ACTMD ; Q9YC01, PSA_AERPE ; DR O29760, PSA_ARCFU ; A1R6Q8, PSA_ARTAT ; B8H8L7, PSA_ARTCA ; DR A0JWY7, PSA_ARTS2 ; C7PVV3, PSA_CATAD ; Q0RLT6, PSA_FRAAA ; DR Q2J9Q4, PSA_FRASC ; A8LH53, PSA_FRASN ; D2S6E3, PSA_GEOOG ; DR D0LDT2, PSA_GORB4 ; B0R2T2, PSA_HALS3 ; P57697, PSA_HALSA ; DR Q18K08, PSA_HALWD ; C7R404, PSA_JONDD ; A6W971, PSA_KINRD ; DR D2Q4H5, PSA_KRIFD ; Q8TPX5, PSA_METAC ; A7I9C7, PSA_METB6 ; DR Q469M6, PSA_METBF ; Q60177, PSA_METJA ; Q8TYB7, PSA_METKA ; DR A4FZT6, PSA_METM5 ; A9A846, PSA_METM6 ; A6VIP0, PSA_METM7 ; DR Q8PTU1, PSA_METMA ; A3CW55, PSA_METMJ ; Q6M0L9, PSA_METMP ; DR B8GEZ3, PSA_METPE ; A5UJS2, PSA_METS3 ; A4YCU9, PSA_METS5 ; DR Q59565, PSA_METTE ; O26782, PSA_METTH ; A6URN9, PSA_METVS ; DR A0QFB6, PSA_MYCA1 ; B1MAI3, PSA_MYCA9 ; Q7TZ14, PSA_MYCBO ; DR A1KKF2, PSA_MYCBP ; C1AQ25, PSA_MYCBT ; A4TB55, PSA_MYCGI ; DR B8ZRF4, PSA_MYCLB ; Q9S375, PSA_MYCLE ; B2HFV5, PSA_MYCMM ; DR Q73YW9, PSA_MYCPA ; A0QZ46, PSA_MYCS2 ; A3Q192, PSA_MYCSJ ; DR A1UHS6, PSA_MYCSK ; Q1B798, PSA_MYCSS ; A5U4D5, PSA_MYCTA ; DR A5WP83, PSA_MYCTF ; C6DPV2, PSA_MYCTK ; O33244, PSA_MYCTU ; DR A0PQT2, PSA_MYCUA ; A1TAP3, PSA_MYCVP ; C8XAQ3, PSA_NAKMY ; DR Q3IPJ1, PSA_NATPD ; Q5YUX3, PSA_NOCFA ; A1SK14, PSA_NOCSJ ; DR Q6L0W3, PSA_PICTO ; Q9V122, PSA_PYRAB ; Q8ZVM1, PSA_PYRAE ; DR Q8U0L6, PSA_PYRFU ; O59219, PSA_PYRHO ; Q5JIU9, PSA_PYRKO ; DR A9WSI0, PSA_RENSM ; C0ZZU6, PSA_RHOE4 ; C1ASP6, PSA_RHOOB ; DR Q0SIG0, PSA_RHOSR ; A4FBY2, PSA_SACEN ; C7MWV6, PSA_SACVD ; DR A8M2A4, PSA_SALAI ; A4X745, PSA_SALTO ; D1BHT8, PSA_SANKS ; DR D3Q556, PSA_STANL ; Q828I7, PSA_STRAW ; Q7AKQ6, PSA_STRCO ; DR B1W307, PSA_STRGG ; D2ATV0, PSA_STRRD ; C9Z4D1, PSA_STRSW ; DR Q4JB24, PSA_SULAC ; C3N5R0, PSA_SULIA ; C4KHD9, PSA_SULIK ; DR C3MQ43, PSA_SULIL ; C3MVG1, PSA_SULIM ; C3NHC6, PSA_SULIN ; DR C3NEC6, PSA_SULIY ; Q9UXC6, PSA_SULSO ; Q975G5, PSA_SULTO ; DR P25156, PSA_THEAC ; D1A2T0, PSA_THECD ; Q47NZ5, PSA_THEFY ; DR C5A2C2, PSA_THEGJ ; O24733, PSA_THEK1 ; B6YSH9, PSA_THEON ; DR C6A459, PSA_THESM ; Q97BZ8, PSA_THEVO ; D1BS27, PSA_XYLCX ; DR Q3T0T1, PSB10_BOVIN; P40306, PSB10_HUMAN; O35955, PSB10_MOUSE; DR Q4KM35, PSB10_RAT ; A5LHX3, PSB11_HUMAN; Q8BG41, PSB11_MOUSE; DR Q9IB84, PSB1A_CARAU; Q9IB83, PSB1B_CARAU; Q9YES4, PSB1_AERPE ; DR P42742, PSB1_ARATH ; Q2TBX6, PSB1_BOVIN ; P34286, PSB1_CAEEL ; DR A8MBW0, PSB1_CALMQ ; A0RU86, PSB1_CENSY ; B8D673, PSB1_DESK1 ; DR Q86A21, PSB1_DICDI ; P40304, PSB1_DROME ; Q8SRH6, PSB1_ENCCU ; DR Q5V4S6, PSB1_HALMA ; D2RQX3, PSB1_HALTV ; P20618, PSB1_HUMAN ; DR A2BN24, PSB1_HYPBU ; A8AA46, PSB1_IGNH4 ; B1L6S7, PSB1_KORCO ; DR A4YIE0, PSB1_METS5 ; O09061, PSB1_MOUSE ; A9A4A1, PSB1_NITMS ; DR O64464, PSB1_ORYSJ ; O82531, PSB1_PETHY ; Q9V247, PSB1_PYRAB ; DR Q8ZYF2, PSB1_PYRAE ; A4WH05, PSB1_PYRAR ; A3MS44, PSB1_PYRCJ ; DR Q8U4C9, PSB1_PYRFU ; O57983, PSB1_PYRHO ; A1RSJ8, PSB1_PYRIL ; DR Q5JDJ9, PSB1_PYRKO ; P18421, PSB1_RAT ; Q53079, PSB1_RHOER ; DR A4X3P0, PSB1_SALTO ; Q9UQY2, PSB1_SCHPO ; A3DN21, PSB1_STAMF ; DR Q82JE3, PSB1_STRAW ; Q4JAY3, PSB1_SULAC ; C3N5N4, PSB1_SULIA ; DR D2PK63, PSB1_SULID ; C4KHB0, PSB1_SULIK ; C3MQ16, PSB1_SULIL ; DR C3MVD5, PSB1_SULIM ; C3NFX2, PSB1_SULIN ; C3NE98, PSB1_SULIY ; DR D0KRX1, PSB1_SULS9 ; Q980L4, PSB1_SULSO ; Q975U8, PSB1_SULTO ; DR D1A2S9, PSB1_THECD ; C5A7L1, PSB1_THEGJ ; B1YA36, PSB1_THENV ; DR B6YSW2, PSB1_THEON ; A1RWY6, PSB1_THEPD ; C6A2V9, PSB1_THESM ; DR Q9U794, PSB1_TRYBB ; P23724, PSB1_YEAST ; O23714, PSB2A_ARATH; DR O24633, PSB2B_ARATH; Q9YER0, PSB2_AERPE ; Q5E9K0, PSB2_BOVIN ; DR P91477, PSB2_CAEEL ; A8M8R5, PSB2_CALMQ ; A0RXV1, PSB2_CENSY ; DR P0CQ13, PSB2_CRYNB ; P0CQ12, PSB2_CRYNJ ; B8D683, PSB2_DESK1 ; DR Q55DY7, PSB2_DICDI ; Q9VQE5, PSB2_DROME ; Q8SRF1, PSB2_ENCCU ; DR Q5V1D5, PSB2_HALMA ; D2RUI0, PSB2_HALTV ; P49721, PSB2_HUMAN ; DR A2BN27, PSB2_HYPBU ; A8AB58, PSB2_IGNH4 ; B1L6X8, PSB2_KORCO ; DR A4YJ04, PSB2_METS5 ; Q9R1P3, PSB2_MOUSE ; Q9P6U7, PSB2_NEUCR ; DR A9A2U7, PSB2_NITMS ; Q9LST6, PSB2_ORYSJ ; A5DB52, PSB2_PICGU ; DR Q9V0N9, PSB2_PYRAB ; Q8ZST5, PSB2_PYRAE ; A4WMZ0, PSB2_PYRAR ; DR A3MXQ6, PSB2_PYRCJ ; Q8U125, PSB2_PYRFU ; O50110, PSB2_PYRHO ; DR A1RTI7, PSB2_PYRIL ; Q5JHL8, PSB2_PYRKO ; P40307, PSB2_RAT ; DR Q53083, PSB2_RHOER ; A4X744, PSB2_SALTO ; Q09720, PSB2_SCHPO ; DR A3DN27, PSB2_STAMF ; Q828I8, PSB2_STRAW ; Q4JAA8, PSB2_SULAC ; DR C3MZI0, PSB2_SULIA ; D2PDG6, PSB2_SULID ; C4KIR0, PSB2_SULIK ; DR C3MRE5, PSB2_SULIL ; C3MY41, PSB2_SULIM ; C3NHF1, PSB2_SULIN ; DR C3N7K2, PSB2_SULIY ; D0KTH0, PSB2_SULS9 ; Q9UXF3, PSB2_SULSO ; DR Q975D1, PSB2_SULTO ; D1A3V2, PSB2_THECD ; C5A2D5, PSB2_THEGJ ; DR B1YDJ0, PSB2_THENV ; B6YXV3, PSB2_THEON ; A1RX71, PSB2_THEPD ; DR C6A3R1, PSB2_THESM ; Q9NHC6, PSB2_TRYBB ; P22141, PSB2_YEAST ; DR Q9XI05, PSB3A_ARATH; O81153, PSB3B_ARATH; P33672, PSB3_BOVIN ; DR Q23237, PSB3_CAEEL ; Q55D66, PSB3_DICDI ; Q9XYN7, PSB3_DROME ; DR Q9N9W8, PSB3_GIAIN ; P49720, PSB3_HUMAN ; Q9R1P1, PSB3_MOUSE ; DR O73817, PSB3_ONCMY ; Q9LST7, PSB3_ORYSJ ; O65084, PSB3_PICMA ; DR P40112, PSB3_RAT ; Q9Y7T8, PSB3_SCHPO ; Q9NDA1, PSB3_TRYBB ; DR P25451, PSB3_YEAST ; Q7DLR9, PSB4_ARATH ; Q3T108, PSB4_BOVIN ; DR Q556Q0, PSB4_DICDI ; Q9VNA5, PSB4_DROME ; Q8SS01, PSB4_ENCCU ; DR P28070, PSB4_HUMAN ; P99026, PSB4_MOUSE ; Q29384, PSB4_PIG ; DR P34067, PSB4_RAT ; Q9USQ9, PSB4_SCHPO ; P28024, PSB4_XENLA ; DR P30657, PSB4_YEAST ; O23717, PSB5A_ARATH; Q9LIP2, PSB5B_ARATH; DR Q32KL2, PSB5_BOVIN ; P34065, PSB5_CHICK ; Q54BC8, PSB5_DICDI ; DR P28074, PSB5_HUMAN ; O55234, PSB5_MOUSE ; Q5R8S2, PSB5_PONAB ; DR P28075, PSB5_RAT ; P30655, PSB5_SCHPO ; O24361, PSB5_SPIOL ; DR P30656, PSB5_YEAST ; Q8LD27, PSB6_ARATH ; Q3MHN0, PSB6_BOVIN ; DR Q55GJ6, PSB6_DICDI ; Q8SR11, PSB6_ENCCU ; P28072, PSB6_HUMAN ; DR Q60692, PSB6_MOUSE ; P28073, PSB6_RAT ; O43063, PSB6_SCHPO ; DR P93395, PSB6_TOBAC ; P38624, PSB6_YEAST ; O23710, PSB7A_ARATH; DR Q7DLS1, PSB7B_ARATH; Q2TBP0, PSB7_BOVIN ; Q54QR2, PSB7_DICDI ; DR Q8SQN7, PSB7_ENCCU ; Q99436, PSB7_HUMAN ; P70195, PSB7_MOUSE ; DR A1XQU1, PSB7_PIG ; Q9JHW0, PSB7_RAT ; Q09841, PSB7_SCHPO ; DR P25043, PSB7_YEAST ; Q3T112, PSB8_BOVIN ; Q5W416, PSB8_CANFA ; DR P28062, PSB8_HUMAN ; P28063, PSB8_MOUSE ; Q29576, PSB8_PIG ; DR P28064, PSB8_RAT ; Q3SZC2, PSB9_BOVIN ; P28065, PSB9_HUMAN ; DR P28076, PSB9_MOUSE ; O35521, PSB9_MUSDU ; O35522, PSB9_MUSMB ; DR O35523, PSB9_MUSPL ; O35524, PSB9_MUSSI ; Q9PT26, PSB9_ONCMY ; DR Q8UW64, PSB9_ORYLA ; P28077, PSB9_RAT ; Q9DD33, PSB9_SALSA ; DR B5IEE5, PSB_ACIB4 ; A0LU50, PSB_ACIC1 ; C7LYP7, PSB_ACIFD ; DR C6WID8, PSB_ACTMD ; Q9P996, PSB_ARCFU ; D2RGT4, PSB_ARCPA ; DR A1R6Q7, PSB_ARTAT ; B8H8L6, PSB_ARTCA ; A0JWY6, PSB_ARTS2 ; DR C5BVA2, PSB_BEUC1 ; C7PVV2, PSB_CATAD ; D3RX66, PSB_FERPA ; DR Q0RLT7, PSB_FRAAA ; Q2J9Q3, PSB_FRASC ; A8LH54, PSB_FRASN ; DR D2S6E2, PSB_GEOOG ; D0LDT1, PSB_GORB4 ; B9LTS6, PSB_HALLT ; DR C7NVQ4, PSB_HALMD ; B0R4C8, PSB_HALS3 ; Q9HR36, PSB_HALSA ; DR C7NQ99, PSB_HALUD ; D4GYZ1, PSB_HALVD ; Q18GX3, PSB_HALWD ; DR C7R403, PSB_JONDD ; A6W970, PSB_KINRD ; D2Q4H4, PSB_KRIFD ; DR A6UT20, PSB_META3 ; Q8TJB5, PSB_METAC ; A7I841, PSB_METB6 ; DR Q46G14, PSB_METBF ; Q12YV7, PSB_METBU ; C7P6N4, PSB_METFA ; DR Q2FQL8, PSB_METHJ ; Q58634, PSB_METJA ; Q8TW10, PSB_METKA ; DR A2SS78, PSB_METLZ ; A4FYA5, PSB_METM5 ; A9A788, PSB_METM6 ; DR A6VK02, PSB_METM7 ; Q8PZ04, PSB_METMA ; A3CUS9, PSB_METMJ ; DR Q6LZD4, PSB_METMP ; D5EAS6, PSB_METMS ; B8GG66, PSB_METPE ; DR D1Z199, PSB_METPS ; D3E0A3, PSB_METRM ; A5UM14, PSB_METS3 ; DR D3S8M7, PSB_METSF ; Q2NI68, PSB_METST ; Q9P992, PSB_METTE ; DR O27270, PSB_METTH ; A0B5B1, PSB_METTP ; C9REN7, PSB_METVM ; DR A6USJ3, PSB_METVS ; A0QFB5, PSB_MYCA1 ; B1MAI2, PSB_MYCA9 ; DR Q7TZ13, PSB_MYCBO ; A1KKF3, PSB_MYCBP ; C1AQ26, PSB_MYCBT ; DR A4TB64, PSB_MYCGI ; B8ZRF3, PSB_MYCLB ; Q49780, PSB_MYCLE ; DR B2HFV6, PSB_MYCMM ; Q73YW8, PSB_MYCPA ; A0QZ47, PSB_MYCS2 ; DR A3Q193, PSB_MYCSJ ; A1UHS7, PSB_MYCSK ; Q1B797, PSB_MYCSS ; DR A5U4D6, PSB_MYCTA ; A5WP84, PSB_MYCTF ; C6DPV1, PSB_MYCTK ; DR O33245, PSB_MYCTU ; A0PQT3, PSB_MYCUA ; A1TAP4, PSB_MYCVP ; DR C8XAQ4, PSB_NAKMY ; Q74MP5, PSB_NANEQ ; D3SSQ6, PSB_NATMM ; DR Q3IPX1, PSB_NATPD ; Q5YUX2, PSB_NOCFA ; A1SK13, PSB_NOCSJ ; DR Q6L181, PSB_PICTO ; A9WSI1, PSB_RENSM ; C0ZZU7, PSB_RHOE4 ; DR C1ASP7, PSB_RHOOB ; Q0SIF9, PSB_RHOSR ; A4FBY1, PSB_SACEN ; DR C7MWV7, PSB_SACVD ; A8M2A3, PSB_SALAI ; D1BHT9, PSB_SANKS ; DR D3Q557, PSB_STANL ; Q7AKQ5, PSB_STRCO ; B1W306, PSB_STRGG ; DR D2ATV1, PSB_STRRD ; C9Z4D0, PSB_STRSW ; P28061, PSB_THEAC ; DR Q47NZ4, PSB_THEFY ; Q97AZ7, PSB_THEVO ; Q0W2D6, PSB_UNCMA ; DR D1BS26, PSB_XYLCX ; P84799, PSMA_HALDO ; //