ENZYME entry: EC 3.4.25.2

Accepted Name
HslU--HslV peptidase.
Reaction catalysed
ATP-dependent cleavage of peptide bonds with broad specificity
Comment(s)
  • The HslU subunit of the HslU--HslV complex functions as an ATP dependent 'unfoldase'.
  • The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.
  • HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
  • Belongs to peptidase family T1.
Cross-references
BRENDA3.4.25.2
EC2PDB3.4.25.2
ExplorEnz3.4.25.2
PRIAM enzyme-specific profiles3.4.25.2
KEGG Ligand Database for Enzyme Nomenclature3.4.25.2
IUBMB Enzyme Nomenclature3.4.25.2
IntEnz3.4.25.2
MEDLINEFind literature relating to 3.4.25.2
MetaCyc3.4.25.2
UniProtKB/Swiss-Prot
A5FYD8, HSLV_ACICJ;  B9MFS3, HSLV_ACIET;  A3N334, HSLV_ACTP2;  
B3GYW3, HSLV_ACTP7;  B0BSG5, HSLV_ACTPJ;  A6VL80, HSLV_ACTSZ;  
A0KQI7, HSLV_AERHH;  A4SHM2, HSLV_AERS4;  Q8UJ88, HSLV_AGRFC;  
B9JG70, HSLV_AGRRK;  B9JXW5, HSLV_AGRVS;  Q0VMA6, HSLV_ALCBS;  
Q0ACL4, HSLV_ALKEH;  B3EU68, HSLV_AMOA5;  B8JES1, HSLV_ANAD2;  
Q2ILD4, HSLV_ANADE;  A7HDU3, HSLV_ANADF;  Q5P9Z6, HSLV_ANAMM;  
Q2GJ25, HSLV_ANAPZ;  B4UIH9, HSLV_ANASK;  B7GGC6, HSLV_ANOFW;  
O67587, HSLV_AQUAE;  A8ETF7, HSLV_ARCB4;  Q5P502, HSLV_AROAE;  
A1K2I5, HSLV_AZOSB;  C3P5N2, HSLV_BACAA;  C3L797, HSLV_BACAC;  
A0RHK3, HSLV_BACAH;  Q81WK5, HSLV_BACAN;  B7JJA8, HSLV_BACC0;  
P61476, HSLV_BACC1;  B7IUI9, HSLV_BACC2;  C1EP54, HSLV_BACC3;  
B7HDV3, HSLV_BACC4;  B7HLG3, HSLV_BACC7;  A7GRG0, HSLV_BACCN;  
B9IVB9, HSLV_BACCQ;  Q819X6, HSLV_BACCR;  Q636J6, HSLV_BACCZ;  
Q9KA26, HSLV_BACHD;  Q6HEY5, HSLV_BACHK;  Q5WFQ0, HSLV_BACSK;  
A9VT68, HSLV_BACWK;  Q6G5G1, HSLV_BARHE;  Q6G0Q0, HSLV_BARQU;  
Q1LTT6, HSLV_BAUCH;  Q2L1C6, HSLV_BORA1;  Q0SNL5, HSLV_BORAP;  
Q661W9, HSLV_BORBP;  Q7WQZ3, HSLV_BORBR;  Q57209, HSLV_BORBU;  
B7J1M4, HSLV_BORBZ;  B5RLC2, HSLV_BORDL;  B2S007, HSLV_BORHD;  
Q7W215, HSLV_BORPA;  A9IH51, HSLV_BORPD;  Q7VUK0, HSLV_BORPE;  
B5RRB6, HSLV_BORRA;  A1QZ92, HSLV_BORT9;  Q89WM9, HSLV_BRADU;  
A5E8F2, HSLV_BRASB;  A4YJV0, HSLV_BRASO;  C0ZFA7, HSLV_BREBN;  
B2S979, HSLV_BRUA1;  Q2YQZ3, HSLV_BRUA2;  Q57AH8, HSLV_BRUAB;  
A9M9R4, HSLV_BRUC2;  C0RFW8, HSLV_BRUMB;  Q8YE31, HSLV_BRUME;  
A5VT38, HSLV_BRUO2;  B0CJI0, HSLV_BRUSI;  Q8FY11, HSLV_BRUSU;  
P57115, HSLV_BUCAI;  Q8K906, HSLV_BUCAP;  P59581, HSLV_BUCBP;  
Q056X3, HSLV_BUCCC;  B1YPR2, HSLV_BURA4;  Q1BSM9, HSLV_BURCA;  
B1K0G1, HSLV_BURCC;  A0KBG2, HSLV_BURCH;  B4E7Z2, HSLV_BURCJ;  
Q0BAX9, HSLV_BURCM;  Q39BY1, HSLV_BURL3;  A9AC32, HSLV_BURM1;  
Q62EZ9, HSLV_BURMA;  A3NQ63, HSLV_BURP0;  Q63YI3, HSLV_BURPS;  
A4JIR2, HSLV_BURVG;  Q146W9, HSLV_BURXL;  B9MM31, HSLV_CALBD;  
Q8R9Y2, HSLV_CALS4;  A4XIW9, HSLV_CALS8;  A7ZDF4, HSLV_CAMC1;  
A7GYN6, HSLV_CAMC5;  A0RPN4, HSLV_CAMFF;  A7I279, HSLV_CAMHC;  
A8FL81, HSLV_CAMJ8;  A7H4F1, HSLV_CAMJD;  Q9PHK9, HSLV_CAMJE;  
A1VZ22, HSLV_CAMJJ;  Q5HVB1, HSLV_CAMJR;  B9KG99, HSLV_CAMLR;  
Q3AB73, HSLV_CARHZ;  Q9A239, HSLV_CAUCR;  B0T7B0, HSLV_CAUSK;  
B3PI66, HSLV_CELJU;  Q11CL2, HSLV_CHESB;  Q3ASH7, HSLV_CHLCH;  
B3ECB1, HSLV_CHLL2;  Q3B4D9, HSLV_CHLL7;  B3QNN5, HSLV_CHLP8;  
B3EJG6, HSLV_CHLPB;  A1BGP1, HSLV_CHLPD;  A4SER5, HSLV_CHLPM;  
Q8KD62, HSLV_CHLTE;  Q7P113, HSLV_CHRVO;  A9KH30, HSLV_COXBN;  
A9N9F9, HSLV_COXBR;  Q83A95, HSLV_COXBU;  Q1LS59, HSLV_CUPMC;  
Q0KF70, HSLV_CUPNH;  Q476Y4, HSLV_CUPPJ;  B2AGB6, HSLV_CUPTR;  
Q11UQ9, HSLV_CYTH3;  Q47JL9, HSLV_DECAR;  A9BUJ5, HSLV_DELAS;  
C6C0P0, HSLV_DESAD;  Q30ZH5, HSLV_DESAG;  B1I260, HSLV_DESAP;  
B8J0S4, HSLV_DESDA;  B8FRG9, HSLV_DESHD;  Q24UF3, HSLV_DESHY;  
C4XN25, HSLV_DESMR;  A4J5Z6, HSLV_DESRM;  Q72BQ7, HSLV_DESVH;  
B8DKL3, HSLV_DESVM;  A1VDQ7, HSLV_DESVV;  A5EX24, HSLV_DICNV;  
A8LPA8, HSLV_DINSH;  A7ZUE7, HSLV_ECO24;  B7UNQ2, HSLV_ECO27;  
B7MI64, HSLV_ECO45;  B7LA29, HSLV_ECO55;  P0A7C0, HSLV_ECO57;  
B5YZ72, HSLV_ECO5E;  B7NU73, HSLV_ECO7I;  B7MR21, HSLV_ECO81;  
B7M6Y3, HSLV_ECO8A;  C5A099, HSLV_ECOBW;  B1XB98, HSLV_ECODH;  
A8A738, HSLV_ECOHS;  A1AIA7, HSLV_ECOK1;  Q0TAD2, HSLV_ECOL5;  
P0A7B9, HSLV_ECOL6;  B1IVE7, HSLV_ECOLC;  P0A7B8, HSLV_ECOLI;  
B7NFN1, HSLV_ECOLU;  B6I4S5, HSLV_ECOSE;  B1LNN7, HSLV_ECOSM;  
Q1R3Y5, HSLV_ECOUT;  Q3YR20, HSLV_EHRCJ;  Q2GFK0, HSLV_EHRCR;  
Q5FGD0, HSLV_EHRRG;  Q5HAB3, HSLV_EHRRW;  A4WG66, HSLV_ENT38;  
Q834K3, HSLV_ENTFA;  B2VF49, HSLV_ERWT9;  B7LUS2, HSLV_ESCF3;  
C1ABE1, HSLV_GEMAT;  Q5L0N2, HSLV_GEOKA;  C5D8V8, HSLV_GEOSW;  
A4IM88, HSLV_GEOTN;  Q7VKB4, HSLV_HAEDU;  Q4QN50, HSLV_HAEI8;  
A5U9Z6, HSLV_HAEIE;  A5UH05, HSLV_HAEIG;  P43772, HSLV_HAEIN;  
B8F689, HSLV_HAEPS;  Q0I5E1, HSLV_HAES1;  Q2S9P4, HSLV_HAHCH;  
A1WWB6, HSLV_HALHL;  C4K5T1, HSLV_HAMD5;  Q17XG1, HSLV_HELAH;  
Q7VJD3, HSLV_HELHP;  B6JL97, HSLV_HELP2;  B5Z6N8, HSLV_HELPG;  
Q1CU16, HSLV_HELPH;  Q9ZLW2, HSLV_HELPJ;  B2UTX3, HSLV_HELPS;  
O25253, HSLV_HELPY;  A4G989, HSLV_HERAR;  B0US06, HSLV_HISS2;  
Q0C0L2, HSLV_HYPNA;  Q5QV35, HSLV_IDILO;  A6T306, HSLV_JANMA;  
Q28W10, HSLV_JANSC;  B5XZ36, HSLV_KLEP3;  A6TGC2, HSLV_KLEP7;  
Q1IV81, HSLV_KORVE;  Q039E0, HSLV_LACC3;  B3WEA8, HSLV_LACCB;  
Q48734, HSLV_LACLE;  Q88W25, HSLV_LACPL;  Q1WTI9, HSLV_LACS1;  
Q1MQE1, HSLV_LAWIP;  Q5X7B1, HSLV_LEGPA;  A5IGR7, HSLV_LEGPC;  
Q5ZXU1, HSLV_LEGPH;  Q5WYQ9, HSLV_LEGPL;  B0SCD1, HSLV_LEPBA;  
Q04TA2, HSLV_LEPBJ;  Q051M4, HSLV_LEPBL;  Q8GQU1, HSLV_LEPBO;  
B0SKV3, HSLV_LEPBP;  B1Y6R3, HSLV_LEPCP;  Q72RY8, HSLV_LEPIC;  
Q8F3Q4, HSLV_LEPIN;  Q92C74, HSLV_LISIN;  C1L2I6, HSLV_LISMC;  
Q720E3, HSLV_LISMF;  B8DG53, HSLV_LISMH;  Q8Y7J9, HSLV_LISMO;  
A0AI81, HSLV_LISW6;  B1HQJ5, HSLV_LYSSC;  B9EBD3, HSLV_MACCJ;  
A0L3K3, HSLV_MAGMM;  Q2VYI5, HSLV_MAGSA;  P49617, HSLV_MANHA;  
Q65VY2, HSLV_MANSM;  A1TYU6, HSLV_MARHV;  A6W2U5, HSLV_MARMS;  
B7KZ47, HSLV_METC4;  Q606K2, HSLV_METCA;  A9W0F2, HSLV_METEP;  
A2SLA3, HSLV_METPP;  Q2RJP6, HSLV_MOOTA;  Q84F94, HSLV_MYXXA;  
Q1D802, HSLV_MYXXD;  Q2GEM5, HSLV_NEOSM;  Q0AD36, HSLV_NITEC;  
Q82SP7, HSLV_NITEU;  Q1QRX5, HSLV_NITHX;  Q3J8P8, HSLV_NITOC;  
A6Q3Q1, HSLV_NITSB;  Q3SWE6, HSLV_NITWN;  Q8CXH2, HSLV_OCEIH;  
A6WX57, HSLV_OCHA4;  B6JAL5, HSLV_OLICO;  A1B5T1, HSLV_PARDP;  
A7HSH6, HSLV_PARL1;  B2JJX8, HSLV_PARP8;  B2T1N9, HSLV_PARPJ;  
P57969, HSLV_PASMU;  Q6CZ92, HSLV_PECAS;  C6DHM7, HSLV_PECCP;  
Q03FK3, HSLV_PEDPA;  Q3A1V7, HSLV_PELCD;  B4SGR7, HSLV_PELPB;  
A5D2W7, HSLV_PELTS;  C0QS72, HSLV_PERMH;  A9BI45, HSLV_PETMO;  
Q7MYC2, HSLV_PHOLL;  Q6LVI2, HSLV_PHOPR;  B4S817, HSLV_PROA2;  
B4F172, HSLV_PROMH;  Q48PI4, HSLV_PSE14;  Q15N48, HSLV_PSEA6;  
A6VDH4, HSLV_PSEA7;  B7V3E6, HSLV_PSEA8;  Q02EW4, HSLV_PSEAB;  
Q9HUC6, HSLV_PSEAE;  Q1I3U0, HSLV_PSEE4;  Q4KJK2, HSLV_PSEF5;  
C3KAH1, HSLV_PSEFS;  A8F5A7, HSLV_PSELT;  A4XPN7, HSLV_PSEMY;  
Q88D28, HSLV_PSEPK;  Q87V01, HSLV_PSESM;  A1SQW4, HSLV_PSYIN;  
B2U7X2, HSLV_RALPJ;  Q8Y3D7, HSLV_RALSO;  B3PWI6, HSLV_RHIE6;  
Q2KE55, HSLV_RHIEC;  Q1MNB5, HSLV_RHIL3;  Q98CT8, HSLV_RHILO;  
B5ZV98, HSLV_RHILW;  Q92TA9, HSLV_RHIME;  Q21SV8, HSLV_RHOFT;  
P61477, HSLV_RHOPA;  A3PG34, HSLV_RHOS1;  Q3J6B2, HSLV_RHOS4;  
A4WWS1, HSLV_RHOS5;  B9KRG9, HSLV_RHOSK;  C3PN29, HSLV_RICAE;  
A8GMZ9, HSLV_RICAH;  A8GWX0, HSLV_RICB8;  Q1RIB6, HSLV_RICBR;  
A8EZD3, HSLV_RICCK;  Q92II7, HSLV_RICCN;  Q4UM54, HSLV_RICFE;  
Q9ZDK9, HSLV_RICPR;  C4K1X3, HSLV_RICPU;  B0BX21, HSLV_RICRO;  
A8GRL7, HSLV_RICRS;  Q68X53, HSLV_RICTY;  Q16CY0, HSLV_ROSDO;  
Q5LLP2, HSLV_RUEPO;  Q1GCN5, HSLV_RUEST;  Q21H72, HSLV_SACD2;  
B5F0S3, HSLV_SALA4;  Q57HC5, HSLV_SALCH;  B5FPU1, HSLV_SALDC;  
B5QXM1, HSLV_SALEP;  B5RF79, HSLV_SALG2;  B4TCM9, HSLV_SALHS;  
B4T0T9, HSLV_SALNS;  Q5PK45, HSLV_SALPA;  A9MZI2, HSLV_SALPB;  
C0Q442, HSLV_SALPC;  B5BJK9, HSLV_SALPK;  B4TPV3, HSLV_SALSV;  
P0A272, HSLV_SALTI;  P0A271, HSLV_SALTY;  A8GL95, HSLV_SERP5;  
A1S2P5, HSLV_SHEAM;  B8E6E4, HSLV_SHEB2;  A3D9C5, HSLV_SHEB5;  
A6WIH6, HSLV_SHEB8;  A9KYP9, HSLV_SHEB9;  Q12IT9, HSLV_SHEDO;  
Q07WM3, HSLV_SHEFN;  B0TVV3, HSLV_SHEHH;  A3Q9U9, HSLV_SHELP;  
Q8E9V0, HSLV_SHEON;  A8H955, HSLV_SHEPA;  A4Y2S8, HSLV_SHEPC;  
B8CI19, HSLV_SHEPW;  A0L1J8, HSLV_SHESA;  A8FQM0, HSLV_SHESH;  
Q0HED1, HSLV_SHESM;  Q0HZL8, HSLV_SHESR;  B1KK50, HSLV_SHEWM;  
B2TWC8, HSLV_SHIB3;  Q31U58, HSLV_SHIBS;  Q32AA5, HSLV_SHIDS;  
Q0SY57, HSLV_SHIF8;  P0A7C1, HSLV_SHIFL;  Q3YV46, HSLV_SHISS;  
C3MBC6, HSLV_SINFN;  A6UEK8, HSLV_SINMW;  Q2NQY2, HSLV_SODGM;  
Q01Q19, HSLV_SOLUE;  A5VEJ8, HSLV_SPHWW;  A7X1M9, HSLV_STAA1;  
A6U171, HSLV_STAA2;  Q2FHI5, HSLV_STAA3;  Q2FZ29, HSLV_STAA8;  
A5ISD7, HSLV_STAA9;  Q2YXL5, HSLV_STAAB;  Q5HGH9, HSLV_STAAC;  
A6QGF3, HSLV_STAAE;  P65796, HSLV_STAAM;  P65797, HSLV_STAAN;  
Q6GHI2, HSLV_STAAR;  Q6G9W0, HSLV_STAAS;  A8Z3T3, HSLV_STAAT;  
P65798, HSLV_STAAW;  B9DPG5, HSLV_STACT;  Q5HPT9, HSLV_STAEQ;  
Q8CPH1, HSLV_STAES;  Q4L5V5, HSLV_STAHJ;  Q49X38, HSLV_STAS1;  
B4SJN0, HSLV_STRM5;  B2FUV7, HSLV_STRMK;  Q30QS8, HSLV_SULDN;  
A6QAX2, HSLV_SULNB;  B2V939, HSLV_SULSY;  A0LEB7, HSLV_SYNFM;  
Q0AYP2, HSLV_SYNWW;  C5BRK9, HSLV_TERTT;  B7IFU1, HSLV_THEAB;  
A6LJK3, HSLV_THEM4;  Q9WYZ1, HSLV_THEMA;  A5IJQ3, HSLV_THEP1;  
B0K9V4, HSLV_THEP3;  B0K1T7, HSLV_THEPX;  B1L8X4, HSLV_THESQ;  
B5YFZ9, HSLV_THEYD;  Q31IL7, HSLV_THICR;  Q3SFW2, HSLV_THIDA;  
B8GTA0, HSLV_THISH;  C4L9X0, HSLV_TOLAT;  P61478, HSLV_TREDE;  
Q383Q5, HSLV_TRYB2;  C5CNE3, HSLV_VARPS;  A1WRK0, HSLV_VEREI;  
A5F4X4, HSLV_VIBC3;  A7MWJ4, HSLV_VIBCB;  Q9KNQ6, HSLV_VIBCH;  
C3LSA4, HSLV_VIBCM;  B5FBL7, HSLV_VIBFM;  Q87T20, HSLV_VIBPA;  
B7VLM6, HSLV_VIBTL;  Q8DCP3, HSLV_VIBVU;  Q7MH57, HSLV_VIBVY;  
Q8D2S6, HSLV_WIGBR;  P61479, HSLV_WOLPM;  B3CLU4, HSLV_WOLPP;  
Q7M8Z6, HSLV_WOLSU;  Q5GRR4, HSLV_WOLTR;  C0R4L3, HSLV_WOLWR;  
Q8PPP8, HSLV_XANAC;  Q3BXU0, HSLV_XANC5;  Q4UYX7, HSLV_XANC8;  
Q8P551, HSLV_XANCP;  Q2NYV8, HSLV_XANOM;  B2IA19, HSLV_XYLF2;  
P65799, HSLV_XYLFA;  P65800, HSLV_XYLFT;  A1JI09, HSLV_YERE8;  
A7FCY5, HSLV_YERP3;  Q1CBE7, HSLV_YERPA;  B2JZC6, HSLV_YERPB;  
Q8ZJJ4, HSLV_YERPE;  A9R6C8, HSLV_YERPG;  Q1CD56, HSLV_YERPN;  
A4TS83, HSLV_YERPP;  Q66G84, HSLV_YERPS;  B1JQ75, HSLV_YERPY;  
Q5NQY4, HSLV_ZYMMO;  

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