ENZYME entry: EC 3.5.1.103

Accepted Name
N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase.
Alternative Name(s)
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase.
Reaction catalysed
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H(2)O <=> 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate
Cofactor(s)
Zn(2+).
Comment(s)
  • This enzyme is considered the key enzyme and rate limiting step in the mycothiol biosynthesis pathway.
  • In addition to acetylase activity, the enzyme possesses weak mycothiol conjugate amidase activity, and shares sequence similarity with mycothiol S-conjugate amidase.
  • Formerly EC 3.1.1.n1.
Cross-references
BRENDA3.5.1.103
EC2PDB3.5.1.103
ExplorEnz3.5.1.103
PRIAM enzyme-specific profiles3.5.1.103
KEGG Ligand Database for Enzyme Nomenclature3.5.1.103
IUBMB Enzyme Nomenclature3.5.1.103
IntEnz3.5.1.103
MEDLINEFind literature relating to 3.5.1.103
MetaCyc3.5.1.103
UniProtKB/Swiss-Prot
C7Q0R3, MSHB1_CATAD;  Q0RKY6, MSHB1_FRAAA;  Q2J7C9, MSHB1_FRASC;  
A4F8G5, MSHB1_SACEN;  C7Q4X5, MSHB2_CATAD;  Q0RCR9, MSHB2_FRAAA;  
Q2J678, MSHB2_FRASC;  A4F9Z0, MSHB2_SACEN;  C7QKE2, MSHB3_CATAD;  
A0LW30, MSHB_ACIC1;  C6WKX3, MSHB_ACTMD;  Q6NI09, MSHB_CORDI;  
Q8FQG1, MSHB_COREF;  A4QD64, MSHB_CORGB;  Q8NRE9, MSHB_CORGL;  
Q4JUD7, MSHB_CORJK;  C4LHT4, MSHB_CORK4;  B1VFT1, MSHB_CORU7;  
A8L1A5, MSHB_FRASN;  D2S9Y0, MSHB_GEOOG;  D0LD40, MSHB_GORB4;  
A6W733, MSHB_KINRD;  D2PN56, MSHB_KRIFD;  A0QCB7, MSHB_MYCA1;  
B1MLH7, MSHB_MYCA9;  Q7U0H2, MSHB_MYCBO;  A1KHW1, MSHB_MYCBP;  
C1AMG5, MSHB_MYCBT;  A4T907, MSHB_MYCGI;  B8ZRQ3, MSHB_MYCLB;  
Q9CBX4, MSHB_MYCLE;  B2HSB3, MSHB_MYCMM;  Q73WP7, MSHB_MYCPA;  
A0R2I7, MSHB_MYCS2;  A3Q4F8, MSHB_MYCSJ;  A1UKE3, MSHB_MYCSK;  
Q1B4P5, MSHB_MYCSS;  A5U1L9, MSHB_MYCTA;  A5WLJ9, MSHB_MYCTF;  
C6DUY7, MSHB_MYCTK;  P9WJN2, MSHB_MYCTO;  P9WJN3, MSHB_MYCTU;  
A0PMQ6, MSHB_MYCUA;  A1TDR0, MSHB_MYCVP;  C8XJN6, MSHB_NAKMY;  
D7B6L8, MSHB_NOCDD;  Q5YQD2, MSHB_NOCFA;  A1SFT8, MSHB_NOCSJ;  
C1A2R3, MSHB_RHOE4;  Q0S424, MSHB_RHOJR;  C1AZH2, MSHB_RHOOB;  
C7MY07, MSHB_SACVD;  A8M3H2, MSHB_SALAI;  A4XB95, MSHB_SALTO;  
D6ZE32, MSHB_SEGRD;  D3PW16, MSHB_STANL;  Q82IJ5, MSHB_STRAW;  
D7BQJ3, MSHB_STRBB;  Q9F344, MSHB_STRCO;  B1W1K9, MSHB_STRGG;  
D2B0T1, MSHB_STRRD;  C9ZBY0, MSHB_STRSW;  D6Y7M2, MSHB_THEBD;  
D1A8M1, MSHB_THECD;  Q47SP3, MSHB_THEFY;  D5UVX0, MSHB_TSUPD;  

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