ENZYME entry: EC 3.5.1.112

Accepted Name
2'-N-acetylparomamine deacetylase.
Reaction catalysed
2'-N-acetylparomamine + H(2)O <=> paromamine + acetate
Comment(s)
  • Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.
  • The enzyme from the bacterium Streptomyces fradiae can also accept 2'''-acetyl-6'''-hydroxyneomycin C as substrate, cf. EC 3.5.1.113.
Cross-references
BRENDA3.5.1.112
EC2PDB3.5.1.112
ExplorEnz3.5.1.112
PRIAM enzyme-specific profiles3.5.1.112
KEGG Ligand Database for Enzyme Nomenclature3.5.1.112
IUBMB Enzyme Nomenclature3.5.1.112
IntEnz3.5.1.112
MEDLINEFind literature relating to 3.5.1.112
MetaCyc3.5.1.112
UniProtKB/Swiss-Prot
Q4H4F3, BTRD_BACCI;  Q53U10, NEOL_STRFR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
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