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ENZYME entry: EC 184.108.40.206
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|Protein N-terminal asparagine amidohydrolase.
|N-terminal L-asparaginyl-[protein] + H(2)O <=> N-terminal L-aspartyl-[protein] + NH(3)|
- This enzyme participates in the eukaryotic ubiquitin-dependent
Arg/N-end rule pathway of protein degradation, promoting the turnover
of intracellular proteins that initiate with Met-Asn.
- Following the acetylation and removal of the initiator methionine,
the exposed N-terminal asparagine is deaminated, resulting in its
conversion to L-aspartate.
- The latter serves as a substrate for EC 220.127.116.11 making the protein
susceptible to arginylation, polyubiquitination and degradation as
specified by the N-end rule.
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
entries corresponding to 3.5.1.-
entries corresponding to 3.5.-.-
entries corresponding to 3.-.-.-