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ENZYME

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ENZYME entry: EC 3.5.1.121

Accepted Name
protein N-terminal asparagine amidohydrolase
Reaction catalysed
H(+) + H2O + N-terminal L-asparaginyl-[protein] = N-terminal L-aspartyl-[protein] + NH4(+)
Comment(s)
  • This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn.
  • Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to L-aspartate.
  • The latter serves as a substrate for EC 2.3.2.8 making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
Cross-references
BRENDA3.5.1.121
EC2PDB3.5.1.121
ExplorEnz3.5.1.121
PRIAM enzyme-specific profiles3.5.1.121
KEGG Ligand Database for Enzyme Nomenclature3.5.1.121
IUBMB Enzyme Nomenclature3.5.1.121
IntEnz3.5.1.121
MEDLINEFind literature relating to 3.5.1.121
MetaCyc3.5.1.121
Rhea expert-curated reactions3.5.1.121
UniProtKB/Swiss-Prot
O64876, NTAN1_ARATHQ96AB6, NTAN1_HUMANQ64311, NTAN1_MOUSE
Q28955, NTAN1_PIG

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-