ID 3.5.1.122 DE protein N-terminal glutamine amidohydrolase. CA H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] CA + NH4(+). CC -!- This enzyme participates in the eukaryotic ubiquitin-dependent CC Arg/N-end rule pathway of protein degradation, promoting the turnover CC of intracellular proteins that initiate with Met-Gln. CC -!- Following the acetylation and removal of the initiator methionine, CC the exposed N-terminal glutamine is deaminated, resulting in its CC conversion to L-glutamate. CC -!- The latter serves as a substrate for EC 2.3.2.8 making the protein CC susceptible to arginylation, polyubiquitination and degradation as CC specified by the N-end rule. DR Q7Q968, NTAQ1_ANOGA; O22944, NTAQ1_ARATH; Q3T0D3, NTAQ1_BOVIN; DR A8Y183, NTAQ1_CAEBR; Q21775, NTAQ1_CAEEL; Q1LWX3, NTAQ1_DANRE; DR B3MCF3, NTAQ1_DROAN; B3NQ86, NTAQ1_DROER; B4J8A0, NTAQ1_DROGR; DR Q7K2Y9, NTAQ1_DROME; B4KPY6, NTAQ1_DROMO; Q28WL0, NTAQ1_DROPS; DR B4HSF8, NTAQ1_DROSE; B4QGZ1, NTAQ1_DROSI; B4MDT2, NTAQ1_DROVI; DR B4MQL4, NTAQ1_DROWI; B4P6V4, NTAQ1_DROYA; Q96HA8, NTAQ1_HUMAN; DR Q80WB5, NTAQ1_MOUSE; B8AXU2, NTAQ1_ORYSI; Q60E61, NTAQ1_ORYSJ; DR Q5BJV9, NTAQ1_RAT ; Q5PPU8, NTAQ1_XENLA; //