ID   3.5.1.124
DE   protein deglycase.
AN   glyoxylase III.
CA   (1) H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) +
CA   L-arginyl-[protein] + lactate.
CA   (2) H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) +
CA   L-lysyl-[protein] + lactate.
CA   (3) H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) +
CA   L-cysteinyl-[protein] + lactate.
CC   -!- The enzyme, previously thought to be a glyoxalase, acts on glycated
CC       L-arginine, L-lysine, and L-cysteine residues within proteins that
CC       have been attacked and modified by glyoxal or 2-oxopropanal.
CC   -!- The attack forms hemithioacetal in the case of cysteines and
CC       aminocarbinols in the case of arginines and lysines.
CC   -!- The enzyme repairs the amino acids, releasing glycolate or lactate
CC       (70-80% (S)-lactate and 20-30% (R)-lactate), depending on whether the
CC       attacking agent was glyoxal or 2-oxopropanal, respectively.
DR   Q9V1F8, DEGLY_PYRAB;  Q51732, DEGLY_PYRFU;  O59413, DEGLY_PYRHO;
DR   Q5JGM7, DEGLY_THEKO;  A7ZN88, HCHA_ECO24 ;  B7MCM0, HCHA_ECO45 ;
DR   B7L8Y4, HCHA_ECO55 ;  Q8XB78, HCHA_ECO57 ;  B5YSJ3, HCHA_ECO5E ;
DR   B7NRB5, HCHA_ECO7I ;  B7MWF3, HCHA_ECO81 ;  B7M3A5, HCHA_ECO8A ;
DR   C4ZQN7, HCHA_ECOBW ;  B1X6B7, HCHA_ECODH ;  A8A1G6, HCHA_ECOHS ;
DR   A1ACB2, HCHA_ECOK1 ;  Q0TGM8, HCHA_ECOL5 ;  P59331, HCHA_ECOL6 ;
DR   B1IZU5, HCHA_ECOLC ;  P31658, HCHA_ECOLI ;  B7NBV8, HCHA_ECOLU ;
DR   B6I112, HCHA_ECOSE ;  B1LQP2, HCHA_ECOSM ;  Q1RAH5, HCHA_ECOUT ;
DR   B7UX51, HCHA_PSEA8 ;  Q02IV5, HCHA_PSEAB ;  Q9I4K0, HCHA_PSEAE ;
DR   B2TWL8, HCHA_SHIB3 ;  Q0T3G3, HCHA_SHIF8 ;  P59332, HCHA_SHIFL ;
DR   Q3Z0M5, HCHA_SHISS ;  A7WYY0, HCHA_STAA1 ;  A6TZ28, HCHA_STAA2 ;
DR   Q2FJ89, HCHA_STAA3 ;  Q2G0M7, HCHA_STAA8 ;  A5IQA5, HCHA_STAA9 ;
DR   Q2YSB0, HCHA_STAAB ;  Q5HIC4, HCHA_STAAC ;  A6QEK3, HCHA_STAAE ;
DR   P64312, HCHA_STAAM ;  P64313, HCHA_STAAN ;  Q6GJB7, HCHA_STAAR ;
DR   Q6GBT6, HCHA_STAAS ;  A8YZP8, HCHA_STAAT ;  Q8NXY2, HCHA_STAAW ;
DR   Q5E946, PARK7_BOVIN;  Q8UW59, PARK7_CHICK;  Q95LI9, PARK7_CHLAE;
DR   Q5XJ36, PARK7_DANRE;  Q99497, PARK7_HUMAN;  Q7TQ35, PARK7_MESAU;
DR   Q99LX0, PARK7_MOUSE;  O88767, PARK7_RAT  ;  Q46948, YAJL_ECOLI ;
DR   P55880, YAJL_SALTY ;  P45470, YHBO_ECOLI ;
//