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ENZYME

ENZYME entry: EC 3.5.1.97

Accepted Name
acyl-homoserine-lactone acylase
Alternative Name(s)
acyl-homoserine lactone acylase
AHL-acylase
N-acyl-homoserine lactone acylase
quorum-quenching AHL acylase
quorum-quenching enzyme
Reaction catalysed
an N-acyl-L-homoserine lactone + H2O <=> a carboxylate + L-homoserine lactone
Comment(s)
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria.
  • This quorum-quenching enzyme removes the fatty-acid side chain from the homoserine lactone ring of AHL-dependent quorum-sensing signal molecules.
  • It has broad specificity for AHLs with side changes ranging in length from 11 to 14 carbons.
  • Substituents at the 3'-position, as found in N-(3-oxododecanoyl)-L- homoserine lactone, do not affect this activity.
Cross-references
BRENDA3.5.1.97
EC2PDB3.5.1.97
ExplorEnz3.5.1.97
PRIAM enzyme-specific profiles3.5.1.97
KEGG Ligand Database for Enzyme Nomenclature3.5.1.97
IUBMB Enzyme Nomenclature3.5.1.97
IntEnz3.5.1.97
MEDLINEFind literature relating to 3.5.1.97
MetaCyc3.5.1.97
Rhea expert-curated reactions3.5.1.97
UniProtKB/Swiss-Prot
Q48KB0, PVDQ_PSE14Q9I194, PVDQ_PSEAEQ4KCM5, PVDQ_PSEF5
Q3KD51, PVDQ_PSEPFQ88IU8, PVDQ_PSEPKQ884D2, PVDQ_PSESM
Q4ZV08, PVDQ_PSEU2Q48LS4, QUIP_PSE14Q9I4U2, QUIP_PSEAE
Q4KH86, QUIP_PSEF5Q3KH00, QUIP_PSEPFQ88NU6, QUIP_PSEPK
Q87XP3, QUIP_PSESMQ4ZPM1, QUIP_PSEU2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-