ID   3.5.1.97
DE   acyl-homoserine-lactone acylase.
AN   acyl-homoserine lactone acylase.
AN   AHL-acylase.
AN   N-acyl-homoserine lactone acylase.
AN   quorum-quenching AHL acylase.
AN   quorum-quenching enzyme.
CA   an N-acyl-L-homoserine lactone + H2O = a carboxylate + L-homoserine
CA   lactone.
CC   -!- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial
CC       species and are used by them to regulate the expression of virulence
CC       genes in a process known as quorum-sensing.
CC   -!- Each bacterial cell has a basal level of AHL and, once the population
CC       density reaches a critical level, it triggers AHL-signaling which,
CC       in turn, initiates the expression of particular virulence genes.
CC   -!- Plants or animals capable of degrading AHLs would have a therapeutic
CC       advantage in avoiding bacterial infection as they could prevent AHL-
CC       signaling and the expression of virulence genes in quorum-sensing
CC       bacteria.
CC   -!- This quorum-quenching enzyme removes the fatty-acid side chain from
CC       the homoserine lactone ring of AHL-dependent quorum-sensing signal
CC       molecules.
CC   -!- It has broad specificity for AHLs with side changes ranging in length
CC       from 11 to 14 carbons.
CC   -!- Substituents at the 3'-position, as found in N-(3-oxododecanoyl)-L-
CC       homoserine lactone, do not affect this activity.
DR   Q48KB0, PVDQ_PSE14 ;  Q9I194, PVDQ_PSEAE ;  Q4KCM5, PVDQ_PSEF5 ;
DR   Q3KD51, PVDQ_PSEPF ;  Q88IU8, PVDQ_PSEPK ;  Q884D2, PVDQ_PSESM ;
DR   Q4ZV08, PVDQ_PSEU2 ;  Q48LS4, QUIP_PSE14 ;  Q9I4U2, QUIP_PSEAE ;
DR   Q4KH86, QUIP_PSEF5 ;  Q3KH00, QUIP_PSEPF ;  Q88NU6, QUIP_PSEPK ;
DR   Q87XP3, QUIP_PSESM ;  Q4ZPM1, QUIP_PSEU2 ;
//