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ENZYME

ENZYME entry: EC 3.5.1.98

PURL: https://purl.expasy.org/enzyme/EC/3.5.1.98
Accepted Name
histone deacetylase
Alternative Name(s)
HDAC
Reaction catalysed
N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate
Comment(s)
  • A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone.
  • The reaction of this enzyme is opposite to that of EC 2.3.1.48.
  • Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization.
  • Histone acetylation plays an important role in regulation of gene expression.
  • In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation.
  • May be identical to EC 3.5.1.17.
Cross-references
BRENDA3.5.1.98
EC2PDB3.5.1.98
ExplorEnz3.5.1.98
KEGG Ligand Database for Enzyme Nomenclature3.5.1.98
IUBMB Enzyme Nomenclature3.5.1.98
MEDLINEFind literature relating to 3.5.1.98
MetaCyc3.5.1.98
Rhea expert-curated reactions3.5.1.98
UniProtKB/Swiss-Prot
P56523, CLR3_SCHPOO59702, CLR6_SCHPOQ9M1N8, HDA10_ARATH
Q55FN5, HDA11_DICDIQ96DB2, HDA11_HUMANQ9GKU5, HDA11_MACFA
Q91WA3, HDA11_MOUSEQ55BW2, HDA12_DICDIQ8GXJ1, HDA15_ARATH
Q9LXN8, HDA17_ARATHQ8LRK8, HDA18_ARATHO22446, HDA19_ARATH
P56521, HDA19_MAIZEQ91695, HDA1A_XENLAO42227, HDA1B_XENLA
O17695, HDA1_CAEELQ5A960, HDA1_CANALP53973, HDA1_YEAST
Q54X15, HDA21_DICDIQ54VQ7, HDA22_DICDIQ944K3, HDA2_ARATH
Q09440, HDA2_CAEELQ613L4, HDA4_CAEBRO17323, HDA4_CAEEL
Q8RX28, HDA5_ARATHQ9FML2, HDA6_ARATHQ20296, HDA6_CAEEL
Q9FH09, HDA7_ARATHQ94EJ2, HDA8_ARATHQ6PBI4, HDA9B_DANRE
Q8H0W2, HDA9_ARATHQ32PJ8, HDAC1_BOVINP56517, HDAC1_CHICK
Q94517, HDAC1_DROMEQ13547, HDAC1_HUMANO09106, HDAC1_MOUSE
Q7Y0Y8, HDAC1_ORYSJQ5RAG0, HDAC1_PONABQ4QQW4, HDAC1_RAT
P56518, HDAC1_STRPUP56519, HDAC2_CHICKQ92769, HDAC2_HUMAN
P70288, HDAC2_MOUSEQ6YV04, HDAC2_ORYSJP56520, HDAC3_CHICK
Q803C3, HDAC3_DANREO15379, HDAC3_HUMANO88895, HDAC3_MOUSE
Q7Y0Y6, HDAC3_ORYSJQ5RB76, HDAC3_PONABQ6P6W3, HDAC3_RAT
Q4SFA0, HDAC3_TETNGQ6IRL9, HDAC3_XENLAQ28DV3, HDAC3_XENTR
P83038, HDAC4_CHICKP56524, HDAC4_HUMANQ6NZM9, HDAC4_MOUSE
Q99P99, HDAC4_RATQ80ZH1, HDAC5_CRIGRQ9UQL6, HDAC5_HUMAN
Q9Z2V6, HDAC5_MOUSEQ5R902, HDAC5_PONABQ8WUI4, HDAC7_HUMAN
Q8C2B3, HDAC7_MOUSEQ99P96, HDAC7_RATQ0VCB2, HDAC8_BOVIN
Q7SXM0, HDAC8_DANREQ9BY41, HDAC8_HUMANQ8VH37, HDAC8_MOUSE
B1WC68, HDAC8_RATQ6GPA7, HDAC8_XENLAB1H369, HDAC8_XENTR
Q5ZKH6, HDAC9_CHICKQ9UKV0, HDAC9_HUMANQ99N13, HDAC9_MOUSE
Q9YGY4, HDAC9_XENLAQ12214, HOS1_YEASTP53096, HOS2_YEAST
Q02959, HOS3_YEASTO13298, PHD1_SCHPOP32561, RPD3_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-