ENZYME entry: EC 3.5.1.98

Accepted Name
Histone deacetylase.
Alternative Name(s)
HDAC.
Reaction catalysed
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Comment(s)
  • A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone.
  • The reaction of this enzyme is opposite to that of EC 2.3.1.48.
  • Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization.
  • Histone acetylation plays an important role in regulation of gene expression.
  • In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation.
  • May be identical to EC 3.5.1.17.
Cross-references
BRENDA3.5.1.98
EC2PDB3.5.1.98
ExplorEnz3.5.1.98
PRIAM enzyme-specific profiles3.5.1.98
KEGG Ligand Database for Enzyme Nomenclature3.5.1.98
IUBMB Enzyme Nomenclature3.5.1.98
IntEnz3.5.1.98
MEDLINEFind literature relating to 3.5.1.98
MetaCyc3.5.1.98
UniProtKB/Swiss-Prot
P56523, CLR3_SCHPO;  O59702, CLR6_SCHPO;  Q9M1N8, HDA10_ARATH;  
Q969S8, HDA10_HUMAN;  Q6P3E7, HDA10_MOUSE;  Q569C4, HDA10_RAT;  
Q55FN5, HDA11_DICDI;  Q96DB2, HDA11_HUMAN;  Q9GKU5, HDA11_MACFA;  
Q91WA3, HDA11_MOUSE;  Q55BW2, HDA12_DICDI;  Q941D6, HDA14_ARATH;  
Q8GXJ1, HDA15_ARATH;  Q9LXN8, HDA17_ARATH;  Q8LRK8, HDA18_ARATH;  
O22446, HDA19_ARATH;  P56521, HDA19_MAIZE;  Q91695, HDA1A_XENLA;  
O42227, HDA1B_XENLA;  O17695, HDA1_CAEEL;  P53973, HDA1_YEAST;  
Q54X15, HDA21_DICDI;  Q54VQ7, HDA22_DICDI;  Q944K3, HDA2_ARATH;  
Q09440, HDA2_CAEEL;  Q613L4, HDA4_CAEBR;  O17323, HDA4_CAEEL;  
Q8RX28, HDA5_ARATH;  Q9FML2, HDA6_ARATH;  Q20296, HDA6_CAEEL;  
Q9FH09, HDA7_ARATH;  Q94EJ2, HDA8_ARATH;  Q6PBI4, HDA9B_DANRE;  
Q8H0W2, HDA9_ARATH;  Q32PJ8, HDAC1_BOVIN;  P56517, HDAC1_CHICK;  
Q94517, HDAC1_DROME;  Q13547, HDAC1_HUMAN;  O09106, HDAC1_MOUSE;  
Q5RAG0, HDAC1_PONAB;  Q4QQW4, HDAC1_RAT;  P56518, HDAC1_STRPU;  
P56519, HDAC2_CHICK;  Q92769, HDAC2_HUMAN;  P70288, HDAC2_MOUSE;  
P56520, HDAC3_CHICK;  Q803C3, HDAC3_DANRE;  O15379, HDAC3_HUMAN;  
O88895, HDAC3_MOUSE;  Q5RB76, HDAC3_PONAB;  Q6P6W3, HDAC3_RAT;  
Q4SFA0, HDAC3_TETNG;  Q6IRL9, HDAC3_XENLA;  Q28DV3, HDAC3_XENTR;  
P83038, HDAC4_CHICK;  P56524, HDAC4_HUMAN;  Q6NZM9, HDAC4_MOUSE;  
Q99P99, HDAC4_RAT;  Q80ZH1, HDAC5_CRIGR;  Q9UQL6, HDAC5_HUMAN;  
Q9Z2V6, HDAC5_MOUSE;  Q5R902, HDAC5_PONAB;  Q9UBN7, HDAC6_HUMAN;  
Q9Z2V5, HDAC6_MOUSE;  Q8WUI4, HDAC7_HUMAN;  Q8C2B3, HDAC7_MOUSE;  
Q99P96, HDAC7_RAT;  Q0VCB2, HDAC8_BOVIN;  Q7SXM0, HDAC8_DANRE;  
Q9BY41, HDAC8_HUMAN;  Q8VH37, HDAC8_MOUSE;  B1WC68, HDAC8_RAT;  
Q6GPA7, HDAC8_XENLA;  B1H369, HDAC8_XENTR;  Q5ZKH6, HDAC9_CHICK;  
Q9UKV0, HDAC9_HUMAN;  Q99N13, HDAC9_MOUSE;  Q9YGY4, HDAC9_XENLA;  
Q12214, HOS1_YEAST;  P53096, HOS2_YEAST;  Q02959, HOS3_YEAST;  
O13298, PHD1_SCHPO;  P32561, RPD3_YEAST;  

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