ENZYME entry: EC 3.5.2.15

Accepted Name
Cyanuric acid amidohydrolase.
Reaction catalysed
Cyanuric acid + H(2)O <=> biuret + CO(2)
Comment(s)
  • Along with EC 3.5.1.54 and EC 3.5.1.84, forms part of the cyanuric- acid metabolism pathway, which degrades s-triazide herbicides, such as atrazine (2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5- triazine), in bacteria.
  • A key enzyme in the pathway, catalyzing the ring cleavage of cyanuric acid.
  • Specific for cyanuric acid as substrate as neither the structurally related compounds ammeline (2,4-diamino-6-hydroxy-s-triazine) and ammelide (2-amino-4,6-dihydroxy-s-triazine) nor a number of pyrimidine compounds, such as uracil and cytosine, can act as substrates.
Cross-references
BRENDA3.5.2.15
EC2PDB3.5.2.15
ExplorEnz3.5.2.15
PRIAM enzyme-specific profiles3.5.2.15
KEGG Ligand Database for Enzyme Nomenclature3.5.2.15
IUBMB Enzyme Nomenclature3.5.2.15
IntEnz3.5.2.15
MEDLINEFind literature relating to 3.5.2.15
MetaCyc3.5.2.15
UniProtKB/Swiss-Prot
A8IKD2, CAH_AZOC5;  Q89E06, CAH_BRADU;  H0SH23, CAH_BRAS3;  
P0A3V4, CAH_ENTCL;  B0UET5, CAH_METS4;  Q2RGM7, CAH_MOOTA;  
W6RJ11, CAH_PSEP5;  P58329, CAH_PSESD;  P0A3V5, CAH_PSESP;  
F4CUJ4, CAH_PSEUX;  Q1M7F3, CAH_RHIL3;  C6BAU4, CAH_RHILS;  
H8ZKW0, CAH_RHOSO;  U3N9N6, CAH_SARSX;  

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