ENZYME entry: EC 3.5.2.17

Accepted Name
Hydroxyisourate hydrolase.
Alternative Name(s)
5-hydroxyisourate hydrolase.
HIUHase.
Reaction catalysed
5-hydroxyisourate + H(2)O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
Comment(s)
  • The reaction is the first stage in the conversion of 5-hydroxyisourate into (S)-allantoin.
  • This reaction will also occur spontaneously, but more slowly.
Cross-references
BRENDA3.5.2.17
EC2PDB3.5.2.17
ExplorEnz3.5.2.17
PRIAM enzyme-specific profiles3.5.2.17
KEGG Ligand Database for Enzyme Nomenclature3.5.2.17
IUBMB Enzyme Nomenclature3.5.2.17
IntEnz3.5.2.17
MEDLINEFind literature relating to 3.5.2.17
MetaCyc3.5.2.17
UniProtKB/Swiss-Prot
Q21882, HIUH1_CAEEL;  Q92VB9, HIUH1_RHIME;  O44578, HIUH2_CAEEL;  
Q92UG5, HIUH2_RHIME;  Q9KET9, HIUH_BACHD;  O32142, HIUH_BACSU;  
Q8YFU1, HIUH_BRUME;  Q8G228, HIUH_BRUSU;  Q9A545, HIUH_CAUCR;  
Q06S87, HIUH_DANRE;  Q9RV69, HIUH_DEIRA;  Q8XB75, HIUH_ECO57;  
P76341, HIUH_ECOLI;  Q9CRB3, HIUH_MOUSE;  Q9I3J5, HIUH_PSEAE;  
Q8XXJ7, HIUH_RALSO;  Q98CI7, HIUH_RHILO;  Q4VYA5, HIUH_SALDU;  
Q8Z7Q6, HIUH_SALTI;  Q8ZQ52, HIUH_SALTY;  O74492, HIUH_SCHPO;  
Q8S3J3, HIUH_SOYBN;  Q9LVM5, TTHL_ARATH;  

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