ENZYME entry: EC 3.5.2.6

Accepted Name
Beta-lactamase.
Alternative Name(s)
Cephalosporinase.
Penicillinase.
Reaction catalysed
A beta-lactam + H(2)O <=> a substituted beta-amino acid
Cofactor(s)
Zinc.
Comment(s)
  • Zinc is only requires in class-B enzymes.
  • A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins.
  • Formerly EC 3.5.2.8.
Cross-references
PROSITEPDOC00134 ; PDOC00606
BRENDA3.5.2.6
EC2PDB3.5.2.6
ExplorEnz3.5.2.6
PRIAM enzyme-specific profiles3.5.2.6
KEGG Ligand Database for Enzyme Nomenclature3.5.2.6
IUBMB Enzyme Nomenclature3.5.2.6
IntEnz3.5.2.6
MEDLINEFind literature relating to 3.5.2.6
MetaCyc3.5.2.6
UniProtKB/Swiss-Prot
P05193, AMPC_CITFR;  P00811, AMPC_ECOLI;  P05364, AMPC_ENTCL;  
Q48743, AMPC_LYSLA;  P94958, AMPC_MORMO;  O69773, AMPC_PROST;  
P24735, AMPC_PSEAE;  P85302, AMPC_PSEFL;  O05465, AMPC_PSYIM;  
P18539, AMPC_SERMA;  P45460, AMPC_YEREN;  Q9S424, BLA13_KLEPN;  
P67920, BLA1_ACTPL;  Q44056, BLA1_AERHY;  P10424, BLA1_BACCE;  
P28018, BLA1_BACMY;  P0AD63, BLA1_ECOLX;  P18251, BLA1_ENTCL;  
P67918, BLA1_HAEIF;  P0AD64, BLA1_KLEPN;  Q59514, BLA1_MORCA;  
P67919, BLA1_PASHA;  P52700, BLA1_STEMA;  Q03680, BLA1_STRCI;  
Q9S169, BLA24_ECOLX;  Q9AHN9, BLA29_KLEPN;  P10425, BLA2_BAC17;  
P04190, BLA2_BACCE;  P0A9Z7, BLA2_ECOLX;  P0A9Z8, BLA2_KLEPN;  
P0A9Z9, BLA2_KLEPO;  P0AA00, BLA2_SALTM;  P96465, BLA2_STEMA;  
P14560, BLA2_STRCI;  Q93LM8, BLA34_ECOLX;  P06548, BLA3_BACCE;  
P30896, BLA3_KLEPN;  Q848S4, BLA46_KLEOX;  P37323, BLA4_KLEPN;  
P0A3M1, BLA5_KLEPN;  P0A3M2, BLA5_PSEAI;  P96348, BLA6_KLEPN;  
O08337, BLA8_ECOLX;  O08498, BLAB1_ELIME;  Q9RB01, BLAB2_ELIME;  
Q9K303, BLAB3_ELIME;  Q9XBN7, BLAB4_ELIME;  Q9KJA9, BLAB5_ELIME;  
Q9KJB0, BLAB6_ELIME;  Q9KJA8, BLAB7_ELIME;  Q9KJA7, BLAB8_ELIME;  
P26918, BLAB_AERHY;  P14488, BLAB_BACCE;  P25910, BLAB_BACFG;  
P52664, BLAB_PROVU;  P52699, BLAB_SERMA;  Q06316, BLAC_AMYLA;  
Q44674, BLAC_BACAM;  P00809, BLAC_BACCE;  P00808, BLAC_BACLI;  
P39824, BLAC_BACSU;  Q45726, BLAC_BACTU;  P30898, BLAC_BACUN;  
P30899, BLAC_BACVU;  P22390, BLAC_CITKO;  P05192, BLAC_KLEPN;  
P0A5I7, BLAC_MYCBO;  A5U493, BLAC_MYCTA;  P0C5C1, BLAC_MYCTU;  
Q9EZQ7, BLAC_NOCAS;  Q5YXD6, BLAC_NOCFA;  P30897, BLAC_PROMI;  
P80298, BLAC_PROVU;  P14171, BLAC_RHOCA;  P80545, BLAC_SERFO;  
P00807, BLAC_STAAU;  P14559, BLAC_STRAL;  P10509, BLAC_STRAU;  
P35391, BLAC_STRBA;  Q06650, BLAC_STRCE;  P35392, BLAC_STRFR;  
P81173, BLAC_STRGR;  P35393, BLAC_STRLA;  Q01166, BLAC_YEREN;  
Q59517, BLAF_MYCFO;  C7C422, BLAN1_KLEPN;  P52663, BLAN_ENTCL;  
P52682, BLAN_SERMA;  P62593, BLAT_ECOLX;  Q48406, BLAT_KLEOX;  
P62594, BLAT_SALTI;  P28585, BLC1_ECOLX;  P74841, BLC2_SALTM;  
P37322, BLC3_PSEAI;  Q51355, BLC4_PSEAI;  O33807, BLC4_SALTM;  
O65975, BLC5_SALTM;  O65976, BLC6_SALTM;  P81781, BLC6_VIBCL;  
E1ANH6, BLC97_ECOLX;  P37321, BLE1_PSEAI;  Q848S6, BLKPC_KLEOX;  
Q9F663, BLKPC_KLEPN;  Q00983, BLL1_PSEAI;  P14489, BLO10_PSEAI;  
Q06778, BLO11_PSEAI;  Q51574, BLO15_PSEAI;  O07293, BLO18_PSEAI;  
Q9R976, BLO19_PSEAI;  P13661, BLO1_ECOLX;  P22391, BLO1_KLEOX;  
O84955, BLO20_PSEAI;  P0A1V9, BLO2_ECOLX;  P23954, BLO2_KLEOX;  
P0A1V8, BLO2_SALTM;  Q51429, BLO3_PSEAI;  Q00982, BLO5_PSEAI;  
P35695, BLO7_ECOLX;  P0A3M4, BLO9_ENTAE;  P0A3M3, BLO9_KLEPN;  
Q03170, BLP1_PSEAI;  P16897, BLP4_PSEAI;  Q47066, BLT1_ECOLX;  
O69395, BLT2_ECOLX;  P0AEB2, DACA_ECOLI;  Q9ZMM1, HCPA_HELPJ;  
O25001, HCPA_HELPY;  O25103, HCPB_HELPY;  Q9ZKB5, HCPC_HELPJ;  
O25728, HCPC_HELPY;  Q9ZMS0, HCPD_HELPJ;  O24968, HCPD_HELPY;  
Q9ZMJ9, HCPE_HELPJ;  O25021, HCPE_HELPY;  Q02940, PENA_BURM1;  
P54427, YBXI_BACSU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.2.-
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