ENZYME entry: EC 3.5.3.21

Accepted Name
Methylenediurea deaminase.
Alternative Name(s)
Methylenediurease.
Reaction catalysed
NH(2)-CO-NH-CH(2)-NH-CO-NH(2) + 2 H(2)O <=> N-(hydroxymethyl)urea + 2 NH(3) + CO(2)
Comment(s)
  • The methylenediurea is hydrolyzed and decarboxylated to give an aminated methylurea, which then spontaneously hydrolyzes to hydroxymethylurea.
  • The enzyme from Ochrobactrum anthropi also hydrolyzes dimethylenetriurea and trimethylenetetraurea as well as ureidoglycolate, which is hydrolyzed to urea and glyoxylate, and allantoate, which is hydrolyzed to ureidoglycolate, ammonia and carbon dioxide.
Cross-references
BRENDA3.5.3.21
EC2PDB3.5.3.21
ExplorEnz3.5.3.21
PRIAM enzyme-specific profiles3.5.3.21
KEGG Ligand Database for Enzyme Nomenclature3.5.3.21
IUBMB Enzyme Nomenclature3.5.3.21
IntEnz3.5.3.21
MEDLINEFind literature relating to 3.5.3.21
MetaCyc3.5.3.21

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