ENZYME entry: EC 3.5.4.25

Accepted Name
GTP cyclohydrolase II.
Reaction catalysed
GTP + 3 H(2)O <=> formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate
Comment(s)
Two C-N bonds are hydrolyzed, releasing formate, with simultaneous removal of the terminal diphosphate.
Cross-references
BRENDA3.5.4.25
EC2PDB3.5.4.25
ExplorEnz3.5.4.25
PRIAM enzyme-specific profiles3.5.4.25
KEGG Ligand Database for Enzyme Nomenclature3.5.4.25
IUBMB Enzyme Nomenclature3.5.4.25
IntEnz3.5.4.25
MEDLINEFind literature relating to 3.5.4.25
MetaCyc3.5.4.25
UniProtKB/Swiss-Prot
P50139, RIB1_PICGU;  Q9P7M9, RIB1_SCHPO;  P38066, RIB1_YEAST;  
P47924, RIBA1_ARATH;  Q6Z234, RIBA1_ORYSJ;  Q0E079, RIBA2_ORYSJ;  
Q9FN89, RIBA3_ARATH;  Q6L506, RIBA3_ORYSJ;  Q6F7N4, RIBA_ACIAD;  
B7GVX4, RIBA_ACIB3;  B7IA66, RIBA_ACIB5;  B2HZQ0, RIBA_ACIBC;  
B0VQB7, RIBA_ACIBS;  A3M9B0, RIBA_ACIBT;  B0V709, RIBA_ACIBY;  
A6VPG3, RIBA_ACTSZ;  A0KJ91, RIBA_AERHH;  B6ENI2, RIBA_ALISL;  
O29766, RIBA_ARCFU;  P43525, RIBA_AZOBR;  C1DLI3, RIBA_AZOVD;  
Q1LTG5, RIBA_BAUCH;  Q7VR05, RIBA_BLOFL;  Q492N9, RIBA_BLOPB;  
P57359, RIBA_BUCAI;  Q8K9Q0, RIBA_BUCAP;  P59555, RIBA_BUCBP;  
Q62BG3, RIBA_BURMA;  A0RR75, RIBA_CAMFF;  A7I3X0, RIBA_CAMHC;  
A8AG83, RIBA_CITK8;  Q47WV5, RIBA_COLP3;  A7MMF7, RIBA_CROS8;  
O68248, RIBA_DEHMU;  A7ZL97, RIBA_ECO24;  B7UR85, RIBA_ECO27;  
B7MLV3, RIBA_ECO45;  B7L4B3, RIBA_ECO55;  P0A7I8, RIBA_ECO57;  
B5YZQ8, RIBA_ECO5E;  B7NVQ1, RIBA_ECO7I;  B7MUB9, RIBA_ECO81;  
B7LY36, RIBA_ECO8A;  C4ZTX2, RIBA_ECOBW;  B1XBM8, RIBA_ECODH;  
A7ZZL5, RIBA_ECOHS;  Q0TI88, RIBA_ECOL5;  Q8FHU5, RIBA_ECOL6;  
B1ITH7, RIBA_ECOLC;  P0A7I7, RIBA_ECOLI;  B7N493, RIBA_ECOLU;  
B6I9Z2, RIBA_ECOSE;  B1LH12, RIBA_ECOSM;  A4WAY6, RIBA_ENT38;  
B7LS01, RIBA_ESCF3;  Q4QNX8, RIBA_HAEI8;  A5UAU5, RIBA_HAEIE;  
A5UG14, RIBA_HAEIG;  P44571, RIBA_HAEIN;  Q2SA07, RIBA_HAHCH;  
C4K8Q4, RIBA_HAMD5;  Q17XC9, RIBA_HELAH;  Q7VK48, RIBA_HELHP;  
B6JM32, RIBA_HELP2;  Q1CT68, RIBA_HELPH;  Q9ZL42, RIBA_HELPJ;  
B2UT29, RIBA_HELPS;  O08315, RIBA_HELPY;  Q0I4A3, RIBA_HISS1;  
B0UUP7, RIBA_HISS2;  B5XS13, RIBA_KLEP3;  A6T7Y5, RIBA_KLEP7;  
Q65SC0, RIBA_MANSM;  A6VWW9, RIBA_MARMS;  Q5F7N6, RIBA_NEIG1;  
A9LZD5, RIBA_NEIM0;  Q9JU99, RIBA_NEIMA;  Q9JZ78, RIBA_NEIMB;  
A1KU62, RIBA_NEIMF;  P57863, RIBA_PASMU;  Q6D5U5, RIBA_PECAS;  
P51618, RIBA_PHOPO;  Q6L1J7, RIBA_PICTO;  B4EW08, RIBA_PROMH;  
A6V055, RIBA_PSEA7;  B7V7R1, RIBA_PSEA8;  Q02SL4, RIBA_PSEAB;  
Q9HWY1, RIBA_PSEAE;  Q1IFL5, RIBA_PSEE4;  C3K2R5, RIBA_PSEFS;  
A5VXW5, RIBA_PSEP1;  B0KL75, RIBA_PSEPG;  Q88QH1, RIBA_PSEPK;  
B1J3G0, RIBA_PSEPW;  Q889Q3, RIBA_PSESM;  A1SSA8, RIBA_PSYIN;  
Q21F24, RIBA_SACD2;  Q57NU9, RIBA_SALCH;  Q5PCY8, RIBA_SALPA;  
P66031, RIBA_SALTI;  P66030, RIBA_SALTY;  A1S528, RIBA_SHEAM;  
B8EF62, RIBA_SHEB2;  A3D367, RIBA_SHEB5;  A6WLV9, RIBA_SHEB8;  
A9KXC4, RIBA_SHEB9;  Q12P94, RIBA_SHEDO;  Q080N2, RIBA_SHEFN;  
B0TL40, RIBA_SHEHH;  A3QFR4, RIBA_SHELP;  Q8EDD1, RIBA_SHEON;  
A8H5U9, RIBA_SHEPA;  A4Y5N5, RIBA_SHEPC;  B8CQ07, RIBA_SHEPW;  
A0KYF8, RIBA_SHESA;  A8FTP1, RIBA_SHESH;  Q0HHF8, RIBA_SHESM;  
Q0HTR2, RIBA_SHESR;  A1RL35, RIBA_SHESW;  B1KLM0, RIBA_SHEWM;  
B2U0G9, RIBA_SHIB3;  Q31ZX1, RIBA_SHIBS;  Q32GQ6, RIBA_SHIDS;  
Q0T5C0, RIBA_SHIF8;  P0A7I9, RIBA_SHIFL;  Q3Z127, RIBA_SHISS;  
O88011, RIBA_STRCO;  C5BS80, RIBA_TERTT;  Q97B83, RIBA_THEVO;  
C4LE64, RIBA_TOLAT;  Q9KSJ3, RIBA_VIBCH;  Q5E5L2, RIBA_VIBF1;  
B5FDS3, RIBA_VIBFM;  Q87NE7, RIBA_VIBPA;  Q8DAG7, RIBA_VIBVU;  
Q8D2J0, RIBA_WIGBR;  Q9PBZ3, RIBA_XYLFA;  Q87D69, RIBA_XYLFT;  
Q8ZEF0, RIBA_YERPE;  Q66AI6, RIBA_YERPS;  A3MZA2, RIBBA_ACTP2;  
B3H0P8, RIBBA_ACTP7;  B0BTN8, RIBBA_ACTPJ;  P50855, RIBBA_ACTPL;  
O66679, RIBBA_AQUAE;  A7Z675, RIBBA_BACA2;  C3P7P7, RIBBA_BACAA;  
C3LIX7, RIBBA_BACAC;  A0RIB3, RIBBA_BACAH;  P51695, RIBBA_BACAM;  
Q81MB6, RIBBA_BACAN;  B7JLW6, RIBBA_BACC0;  Q731I5, RIBBA_BACC1;  
B7IWM5, RIBBA_BACC2;  C1EQY5, RIBBA_BACC3;  B7HAY4, RIBBA_BACC4;  
B7HNM8, RIBBA_BACC7;  A7GSD5, RIBBA_BACCN;  B9IWX4, RIBBA_BACCQ;  
Q818X6, RIBBA_BACCR;  Q635H0, RIBBA_BACCZ;  Q5LHT1, RIBBA_BACFN;  
Q64YT3, RIBBA_BACFR;  Q6HE54, RIBBA_BACHK;  Q5WH08, RIBBA_BACSK;  
P17620, RIBBA_BACSU;  Q8A528, RIBBA_BACTN;  A6KWQ7, RIBBA_BACV8;  
A9VG50, RIBBA_BACWK;  C0ZKW2, RIBBA_BREBN;  Q9PLJ5, RIBBA_CHLMU;  
Q9Z734, RIBBA_CHLPN;  O84736, RIBBA_CHLTR;  A0Q3H7, RIBBA_CLONN;  
O24752, RIBBA_CORAM;  A4QEG9, RIBBA_CORGB;  Q8NQ52, RIBBA_CORGL;  
Q11WK6, RIBBA_CYTH3;  C5D3N0, RIBBA_GEOSW;  A0QI09, RIBBA_MYCA1;  
B1MCA4, RIBBA_MYCA9;  P0A5V1, RIBBA_MYCBO;  A1KIK4, RIBBA_MYCBP;  
C1AN60, RIBBA_MYCBT;  A4TC13, RIBBA_MYCGI;  B2HP67, RIBBA_MYCMM;  
Q741F1, RIBBA_MYCPA;  A5U2B7, RIBBA_MYCTA;  P9WHF0, RIBBA_MYCTO;  
P9WHF1, RIBBA_MYCTU;  A0PPL6, RIBBA_MYCUA;  A1T8K1, RIBBA_MYCVP;  
Q5YTP3, RIBBA_NOCFA;  A6LHN0, RIBBA_PARD8;  Q3B2I6, RIBBA_PELLD;  
B4SE30, RIBBA_PELPB;  B2RIG7, RIBBA_PORG3;  Q7MWK9, RIBBA_PORGI;  
B4S5Y8, RIBBA_PROA2;  A4SFY4, RIBBA_PROVI;  C0ZZE5, RIBBA_RHOE4;  
Q0S0K2, RIBBA_RHOSR;  A8LY38, RIBBA_SALAI;  A4X639, RIBBA_SALTO;  
Q5HF07, RIBBA_STAAC;  Q99TA0, RIBBA_STAAM;  Q7A511, RIBBA_STAAN;  
Q6GFT5, RIBBA_STAAR;  Q6G8G1, RIBBA_STAAS;  Q8NW14, RIBBA_STAAW;  
Q5HNE3, RIBBA_STAEQ;  Q8CNU2, RIBBA_STAES;  Q4L7B1, RIBBA_STAHJ;  
Q49YJ7, RIBBA_STAS1;  Q0AXM5, RIBBA_SYNWW;  P74104, RIBBA_SYNY3;  
Q9X2E6, RIBBA_THEMA;  B0KAI2, RIBBA_THEP3;  B0K0Y9, RIBBA_THEPX;  
B1H0I0, RIBBA_UNCTG;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
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