ENZYME entry: EC 3.5.4.30
| Accepted Name |
|---|
| dCTP deaminase (dUMP-forming).
|
| Reaction catalysed |
|---|
| dCTP + 2 H(2)O <=> dUMP + diphosphate + NH(3) |
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP,
cytosine or deoxycytosine are not deaminated.
- While most bacteria require two enzymes to form dUMP from dCTP
(EC 3.5.4.13 and EC 3.6.1.23), the archaeon Methanocaldococcus
jannaschii uses a single enzyme to carry out both functions.
- This enzyme can also act as a dUTP diphosphatase, but more slowly.
|
| Cross-references |
|---|
| BRENDA | 3.5.4.30 |
| EC2PDB | 3.5.4.30 |
| ExplorEnz | 3.5.4.30 |
| PRIAM enzyme-specific profiles | 3.5.4.30 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.5.4.30 |
| IUBMB Enzyme Nomenclature | 3.5.4.30 |
| IntEnz | 3.5.4.30 |
| MEDLINE | Find literature relating to 3.5.4.30 |
| MetaCyc | 3.5.4.30 |
| UniProtKB/Swiss-Prot |
|
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