ENZYME entry: EC 3.5.4.32

Accepted Name
8-oxoguanine deaminase.
Reaction catalysed
8-oxoguanine + H(2)O <=> urate + NH(3)
Cofactor(s)
Zn(2+).
Comment(s)
  • 8-oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species.
  • If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.
Cross-references
BRENDA3.5.4.32
EC2PDB3.5.4.32
ExplorEnz3.5.4.32
PRIAM enzyme-specific profiles3.5.4.32
KEGG Ligand Database for Enzyme Nomenclature3.5.4.32
IUBMB Enzyme Nomenclature3.5.4.32
IntEnz3.5.4.32
MEDLINEFind literature relating to 3.5.4.32
MetaCyc3.5.4.32
UniProtKB/Swiss-Prot
Q9I6Z0, OXODE_PSEAE

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