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ENZYME entry: EC

Accepted Name
mRNA(cytosine(6666)) deaminase.
Alternative Name(s)
Apolipoprotein B mRNA editing enzyme.
Reaction catalysed
Cytosine(6666) in apolipoprotein B mRNA + H(2)O <=> uracil(6666) in apolipoprotein B mRNA + NH(3)
  • The apolipoprotein B mRNA editing enzyme complex catalyzes the editing of apolipoprotein B mRNA at cytidine(6666) to uridine, thereby transforming the codon for glutamine-2153 to a termination codon.
  • Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport.
  • The catalytic component (APOBEC-1) contains zinc at the active site.
PRIAM enzyme-specific profiles3.5.4.36
KEGG Ligand Database for Enzyme Nomenclature3.5.4.36
IUBMB Enzyme Nomenclature3.5.4.36
MEDLINEFind literature relating to
P51908, ABEC1_MOUSE;  Q694B3, ABEC1_PONPY;  P47855, ABEC1_RABIT;  
P38483, ABEC1_RAT;  Q3SYR3, ABEC2_BOVIN;  Q9Y235, ABEC2_HUMAN;  

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