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ENZYME

ENZYME entry: EC 3.5.4.38

PURL: https://purl.expasy.org/enzyme/EC/3.5.4.38
Accepted Name
single-stranded DNA cytosine deaminase
Alternative Name(s)
activation-induced cytidine deaminase
activation-induced deaminase
Reaction catalysed
a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+)
Comment(s)
  • The enzyme exclusively catalyzes deamination of cytosine in single- stranded DNA.
  • It preferentially deaminates five-nucleotide bubbles.
  • The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G).
  • The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
Cross-references
BRENDA3.5.4.38
EC2PDB3.5.4.38
ExplorEnz3.5.4.38
KEGG Ligand Database for Enzyme Nomenclature3.5.4.38
IUBMB Enzyme Nomenclature3.5.4.38
MEDLINEFind literature relating to 3.5.4.38
MetaCyc3.5.4.38
Rhea expert-curated reactions3.5.4.38
UniProtKB/Swiss-Prot
Q4VDN5, AB3CA_FELCAP31941, ABC3A_HUMANQ9UH17, ABC3B_HUMAN
Q694B5, ABC3C_GORGOQ9NRW3, ABC3C_HUMANQ96AK3, ABC3D_HUMAN
Q8IUX4, ABC3F_HUMANQ7YR25, ABC3G_CHLAEQ694C5, ABC3G_ERYPA
Q694C1, ABC3G_GORGOQ9HC16, ABC3G_HUMANQ694B8, ABC3G_LAGLA
Q694C2, ABC3G_MACFAQ7YR23, ABC3G_MACMUQ694C4, ABC3G_MACNG
Q694B6, ABC3G_PANPAQ7YR24, ABC3G_PANTRQ694B7, ABC3G_PAPAN
Q694C0, ABC3G_PONPYQ694B9, ABC3G_SAGLBA9QA56, ABC3H_FELCA
Q6NTF7, ABC3H_HUMANQ19Q52, ABC3H_MACMUQ1WBT4, ABC3H_PONPY
P60704, ABEC3_CRILOQ99J72, ABEC3_MOUSEP60705, ABEC3_RAT
Q2PT36, AICDA_BOVINQ75W64, AICDA_CANLFQ9GZX7, AICDA_HUMAN
Q9WVE0, AICDA_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-